Bacterial Quorum-Sensing Network Architectures

By Wai‐Leung Ng, B. Bassler. Annual Review of Genetics, 2009

1,617 citations recorded by the source corpus.

Quorum sensing is a cell-cell communication process in which bacteria use the production and detection of extracellular chemicals called autoinducers to monitor cell population density. Quorum sensing allows bacteria to synchronize the gene expression of the group, and thus, act in unison. Here, we review the mechanisms involved in quorum sensing with a focus on the Vibrio harveyi and Vibrio cholerae quorum-sensing systems. We discuss the differences between these two quorum-sensing systems and the differences between them and other paradigmatic bacterial signal transduction systems. We argue that the Vibrio quorum-sensing systems are optimally architected to precisely translate extracellular autoinducer information into internal changes in gene expression. We describe how studies of the V. harveyi and V. cholerae quorum-sensing systems have revealed some of the fundamental mechanisms underpinning the evolution of collective behaviors.

Subfields: Endocrinology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eb751192666d5f54c7f8effe00f5dae7b9a439b2

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Citations in the corpus

Bacterial quorum sensing: its role in virulence and possibilities for its control. (2012, background): “Processes controlled by QS include bioluminescence, sporulation, competence, antibiotic production, biofilm formation, and virulence factor secretion (reviewed in Novick and Geisinger 2008; Ng and Bassler 2009; Williams and Camara 2009).”
Microbial Surface Colonization and Biofilm Development in Marine Environments (2015, background): “involved in the modulation of microbial surface colonization and in the regulation of gene expression in biofilms (414, 728).”
Multi-species biofilms: living with friendly neighbors. (2012, background): “Quorum sensing requires production and release of chemical signal molecules called autoinducers that increase in concentration as a function of cell density but can also depend upon physiological conditions (Ng & Bassler, 2009).”
Interactions between Diatoms and Bacteria (2012, background): “, LuxR), causing a conformational change and triggering a signal transduction cascade that results in the regulation of multiple genes (127).”
Animals in a bacterial world, a new imperative for the life sciences (2013, background): “Biologists now know that bacteria have social behaviors, communicating with each other through chemical signaling, such as quorum sensing (67, 68); more recently, inter-domain quorum signaling between bacteria and their eukaryotic partners has become evident (22, 69-71).”
The hierarchy quorum sensing network in Pseudomonas aeruginosa (2014, background): “This article is published with open access at Springerlink.com and journal.hep.com.cn P ro te in gene expression and biofilm formation (Deng et al., 2011; Ng and Bassler, 2009; Pereira et al., 2013; Whitehead et al., 2001).”
A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation (2013, background): “Q sensing is a process of bacterial communication used to collectively control group behaviors (1, 2).”