Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria

By A. Vendeville, Klaus Winzer, K. Heurlier, C. Tang, K. Hardie. Nature Reviews Microbiology, 2005

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Bacterial Quorum-Sensing Network Architectures (2009, positive): “Nonetheless, some studies suggest that phenotypes observed in luxS mutants of other bacterial species stem from LuxS's role in metabolism of SAM (128).”
Quorum Sensing and Bacterial Social Interactions in Biofilms (2012, background): “The LuxR protein is a cytoplasmic receptor and also functions as a transcriptional activator [11,26,39].”
Genes and Molecules of Lactobacilli Supporting Probiotic Action (2008, background): “cholerae, no obvious phenotype has been associated with the extracellular accumulation of this molecule in most bacteria (260).”
Look who's talking: communication and quorum sensing in the bacterial world (2007, background): “Indeed, it is intriguing that formation of this molecule is so closely coupled with the metabolic flux through the AMC (one molecule of DPD is formed per SAM-dependent methylation event), making it an ideal signal for metabolic activity and cell population density (Beeston & Surette 2002; Winzer et ”