The role of antimicrobial peptides in animal defenses.

By Robert E. W. Hancock, M. Scott. Proceedings of the National Academy of Sciences of the United States of America, 2000

960 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/3041959e58154cf2ed5e58f8fcc4386d6da4ce50

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Hoffmann
2. B. Lemaître
3. Robert E. W. Hancock
4. B. Beutler
5. D. Davidson
6. J. Imler
7. D. Ren
8. A. A. Bahar

In Microbiology

1. J. Hoffmann
2. D. Ren
3. A. A. Bahar
4. Robert E. W. Hancock
5. D. Davidson
6. B. Lemaître
7. J. Imler
8. B. Beutler

Citations in the corpus

• The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses1 (2002, methodology): “We have previously shown that CEMA (a synthetic peptide derived from the sequence of cecropin and melittin) blocks LPS-induced production of inflammatory cytokines and selectively inhibits the ability of LPS to alter gene expression in the RAW 264.7 murine macrophage cell line (8, 36).”
• Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. (2000, background): “…antimiand cathelicidins and the antifungal histatins (reviewed crobial genes (data not shown), indicating that the transin Lehrer and Ganz, 1999; Hancock and Scott, 2000). genes used in this study are adequate reporters. a-defensins were originally characterized as peptides produced in granules…”
• Antimicrobial Peptides (2013, background): “Several types of eukaryotic cells are involved in AMP production such as lymphs, epithelial cells in gastrointestinal and genitourinary systems [29,30], phagocytes [31], and lymphocytes of the immune”
• The evolution and genetics of innate immunity (2001, background): “Antimicrobial proteins cause stasis or lysis of the target organism”
• Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms (2008, background): “Cationic peptides, which have antimicrobial and immunomodulatory activities, are being developed as a promising new class of therapeutically relevant drugs [42].”