The evolution and genetics of innate immunity

By D. Kimbrell, B. Beutler. Nature reviews genetics, 2001

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 (2002, neutral): “E:T Base KO (3) KO (2) KO (1) WT (3) WT (2) WT (1) b a”
Innate immunity: an overview. (2004, background): “The general strategy of innate immune detection is one in which a limited number of receptors are dedicated to the recognition of microbial molecules that are conserved across broad taxa (Kimbrell and Beutler, 2001).”
The mitophagy pathway and its implications in human diseases (2023, background): “302,303 Upon recognition of a pathogen or DAMPs, the upregulation and release of interferons, cytokines, and chemokines recruit immune cells to contain the infection or injury, triggering an in ﬂ ammatory response.”
The Drosophila Toll Signaling Pathway (2011, background): “However, mammalian TLRs are believed to have no role in development (10), whereas the Drosophila Toll pathway is involved both in immunity (7) and developmental processes (2, 11, 12).”