The PAS superfamily: sensors of environmental and developmental signals.

By Yinhong Gu, John B. Hogenesch, Christopher A. Bradfield. Annual Review of Pharmacology and Toxicology, 2000

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Mop3 is an essential component of the master circadian pacemaker in mammals. (2000, background): “The observation that PAS proteins playand Christopher A. Bradfield*§ important roles in maintaining circadian rhythms in most*The McArdle Laboratory for Cancer Research organisms provides support for this idea (Kay, 1997;University of Wisconsin Medical School Reppert, 1998; Gu et al., 2000).”
Inter-kingdom signalling: communication between bacteria and their hosts (2008, background): “AhR is a ligand-induced transcription factor that enters the nucleus and acts as a transcriptional regulator upon engagement by a hydrophobic molecul”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “HIFs belong to a family of transcription factors known for environmental sensing called bHLH-PAS (basic helix-loop-helix-Per-Arnt-Sim) transcription factors (Gu et al., 2000).”
When NRF2 Talks, Who's Listening? (2010, positive): “The aryl hydrocarbon receptor is a ligand-activated member of the bHLH=PAS (basic helix-loop-helix=Per-Arnt-Sim) family of transcription factors that mediates the biologic and toxic effects of its xenobiotic ligands (44).”
Time zones: a comparative genetics of circadian clocks (2001, background): “Although there are no extensive homologies between the proteins of metazoan clocks and those of other kingdoms, Neurospora 's WC-1 and WC-2 each contain PAS MOTIFS”