Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

By J. Peterson, L. Bö, S. Mörk, Ansi Chang, B. Trapp. Annals of Neurology, 2001

1,452 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/301eba1a93aeeaa50e517d5b36de0ae1b258b4c6

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In Developmental Neuroscience

In Neurology

In Pathology and Forensic Medicine

Citations in the corpus

Microglial Activation & Chronic Neurodegeneration (2010, background): “Usually considered an autoimmune disease, multiple sclerosis is associated with lesions within the white and gray matter of the CNS that have increased levels of activated microglia.(82,83) In addition to increases in microglia-released ROS and proinflammatory cytokines, microglia may play a large p”
Review of automatic segmentation methods of multiple sclerosis white matter lesions on conventional magnetic resonance imaging (2013, background): “However, recent advances in neuropathological techniques have revealed that there is significant demyelination occurring in the GM of patients with MS (Peterson et al., 2001).”
Grey Matter Pathology in Multiple Sclerosis (2005, background): “Acute transection of axons and dendrites has been described in grey matter lesions (4).”
Cortical demyelination and diffuse white matter injury in multiple sclerosis. (2005, background): “Keywords: multiple sclerosis; cortical demyelination; normal-appearing white matter; PPMS; SPMS Abbreviations: AMS = acute multiple sclerosis; NAWM = normal-appearing white matter; PLP = proteolipid protein; PPMS = primary progressive multiple sclerosis; RRMS = relapsing-remitting multiple sclerosis”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “Although the mechanisms underlying subpial lesions remain unclear, the inflammatory characteristics of such lesions in chronic-progressive disease are noteworthy: There is a paucity of lymphocyte or monocyte infiltration, as evidenced by sparseness of perivascular cuffs, whereas microglial activatio”
The Immunopathology of Multiple Sclerosis: An Overview (2007, background): “Cortical lesions in progressive MS differ from white matter lesions in several fundamental aspects (12, 13, 47, 71).”
An updated histological classification system for multiple sclerosis lesions (2016, background): “Lucchinetti and colleagues have shown extensive cortical inflammatory T-cell infiltrates in early MS lesions (9), however, especially in patients in the progressive disease phase, inflammatory activity in cortical lesions (especially T cells) is, in general, lower than in the adjacent white matter l”
The relation between inflammation and neurodegeneration in multiple sclerosis brains (2009, background): “Cortical lesions were categorized slightly differently than white matter lesions (Peterson et al., 2001; Dal-Bianco et al., 2008).”
Multiple Sclerosis Pathology. (2018, background): “Different types of cortical lesions are found in the MS brain, and their incidence is different between early relapsing and progressive MS (Kidd et al. 1999; Peterson et al. 2001; Bo et al. 2003).”
The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. (2006, background): “Microglia activation and diffuse axonal injury are typically associated with active lesions in the cortex, but the classical perivascular lymphocytic infiltration characteristic of the white matter plaques is absent (Bo et al., 2003; Peterson et al., 2001; Kutzelnigg et al., 2005).”