Glutathione Transferases

By D. Dixon, R. Edwards. The Arabidopsis Book, 2010

1,745 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2fd79d636cacf52025ffea902e0e4f289fcad1c7

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Citations in the corpus

• The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, unknown): “Moreover, the formation of GSH adducts by GSH S-transferases (GSTs) detoxifies endogenous a,bunsaturated aldehydes, quinones, epoxides, and hydroperoxides, which are formed as secondary metabolites during cell metabolism and electrophilic xenobiotics, such as chemical carcinogens, environmental poll”
• Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling (2014, unknown): “Antioxidant activity associated with GSH is typically mediated by specific enzymes, such as GSH-dependent peroxidase and GST (26).”
• Molecular Mechanisms of Nrf2-Mediated Antioxidant Response (2009, unknown): “Accumulating evidence shows that Nrf2 activation can consequently elevate the expression and enzymatic activities of γGCS/GST as well as the GSH level in cells [90,91].”
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Ethylene oxide is a substrate of the GST iso-enzyme T1 (Hayes et al., 2005).”
• Molecular Mechanism of Heavy Metal Toxicity and Tolerance in Plants: Central Role of Glutathione in Detoxification of Reactive Oxygen Species and Methylglyoxal and in Heavy Metal Chelation (2012, background): “Environmental chemicals and their metabolites detoxified by GST include acrolein, atrazine, and others [280].”
• Toxicity and biochemical changes in the honey bee Apis mellifera exposed to four insecticides under laboratory conditions (2015, background): “GST is a detoxifying enzyme that catalyzes the conjugation of a variety of electrophillic substrates to the thiol group of glutathion (GSH), producing less toxic forms, and it appears to contribute to cellular protection against oxidative damage (Hayes et al. 2005; Mannervik et al. 1985).”
• ROS Regulation During Abiotic Stress Responses in Crop Plants (2015, background): “Some of the ROS-scavenging enzymes, such as GST (Dixon and Edwards, 2010), TRX, and GRX (Meyer et al., 2012), have evolved into large multigene families with varied functions that cope with a variety of adverse environmental conditions.”
• Herbicide Metabolism: Crop Selectivity, Bioactivation, Weed Resistance, and Regulation (2019, background): “As GSTUs and GSTFs are associated with a wide range of plant stress responses (Dixon and Edwards 2010), it was then of interest to determine whether the NTSR-associated GSTs were perturbed by biotic and abiotic stress in A.”
• Mitochondrial Glutathione, a Key Survival Antioxidant (2009, background): “Although several cytosolic GSTs isoforms occur (at least 17 in humans), the only GST present in the mitochondria is the class kappa isoform (57).”
• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, unknown): “Groups of natural and synthetic molecules such as polyphenols and isothiocyanates induce genes encoding GSH biosynthetic enzymes [43, 44], drug-metabolizing enzymes such as NAD(P)H:quinone oxidoreductase-1 (NQO1) [45], glutathione S-transferase (GST) isoenzymes [46, 47], and aldo-keto reductase (AKR”
• Free radicals, antioxidants and functional foods: Impact on human health (2010, unknown): “[57]”
• The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “The vital importance of the GSTs is evidenced by their wide distribution, with specific isoforms abundant in the cytoplasm, endoplasmic reticulum, and the mitochondria (for comprehensive reviews see Hayes et al. 2005; Mannervik et al. 2005).”
• Oxidative stress, inflammation, and cancer: how are they linked? (2010, unknown): “Chemical activation of Nrf2 by pretreatment with tert-butylhydroquinone also increased survival of neuroblastoma cells in response to the three drugs tested [259].”
• An overview of the main pathways of metabolic resistance in insects (2016, background): “GSTs can also metabolise insecticides by facilitating their reductive dehydrochlorination or contribute to the removal of toxic oxygen free radical species produced through the action of pesticides (Hayes et al., 2005).”