Molecular Mechanism of Heavy Metal Toxicity and Tolerance in Plants: Central Role of Glutathione in Detoxification of Reactive Oxygen Species and Methylglyoxal and in Heavy Metal Chelation
By M. A. Hossain, P. Piyatida, J. A. Teixeira da Silva, M. Fujita. 2012
986 citations recorded by the source corpus.
Heavy metal (HM) toxicity is one of the major abiotic stresses leading to hazardous effects in plants. A common consequence of HM toxicity is the excessive accumulation of reactive oxygen species (ROS) and methylglyoxal (MG), both of which can cause peroxidation of lipids, oxidation of protein, inactivation of enzymes, DNA damage and/or interact with other vital constituents of plant cells. Higher plants have evolved a sophisticated antioxidant defense system and a glyoxalase system to scavenge ROS and MG. In addition, HMs that enter the cell may be sequestered by amino acids, organic acids, glutathione (GSH), or by specific metal-binding ligands. Being a central molecule of both the antioxidant defense system and the glyoxalase system, GSH is involved in both direct and indirect control of ROS and MG and their reaction products in plant cells, thus protecting the plant from HM-induced oxidative damage. Recent plant molecular studies have shown that GSH by itself and its metabolizing enzymes—notably glutathione S-transferase, glutathione peroxidase, dehydroascorbate reductase, glutathione reductase, glyoxalase I and glyoxalase II—act additively and coordinately for efficient protection against ROS- and MG-induced damage in addition to detoxification, complexation, chelation and compartmentation of HMs. The aim of this review is to integrate a recent understanding of physiological and biochemical mechanisms of HM-induced plant stress response and tolerance based on the findings of current plant molecular biology research.
Subfields: Molecular Biology, Nutrition and Dietetics, Plant Science
View Paper: https://www.semanticscholar.org/paper/8f335daf975af729fc4117f41cc21b91a22b0116
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
In Nutrition and Dietetics
In Plant Science
Citations in the corpus
- Abiotic Stress in Plants; Stress Perception to Molecular Response and Role of Biotechnological Tools in Stress Resistance (2021, background): “There are several other ways that a plant can deal with HMs including changing the pH of the rhizosphere (resulting in precipitation of HMs), transporting the metallic ions from symplastic to aplastic space using metal transport and carrier proteins, secretion of root exudates such as malate and oxa”
- Heavy metal detoxification and tolerance mechanisms in plants: Implications for phytoremediation (2016, background): “Plants have evolved different mechanisms to tolerate excess concentrations of heavy metals, with more than one mechanismoften observed in the same plant species (Hossain et al. 2012).”
- Heavy Metal Tolerance in Plants: Role of Transcriptomics, Proteomics, Metabolomics, and Ionomics (2016, background): “…molecules depending on the properties like chemical reactivity, redox potential, half-life, and mobility within the cellular system, ultimately leading to a series of destructive processes collectively termed as “oxidative stress” (Mittler, 2002; Sharma and Dietz, 2009; Hossain et al., 2012a,b).”
- Cadmium stress in plants: A critical review of the effects, mechanisms, and tolerance strategies (2020, background): “Generally, these reactive compounds are produced directly by redox active reactions or indirectly by redox inactive reactions such as in the case of Cd by its interaction with functional groups (–SH) of antioxidants and enzymes (Hossain et al., 2012; Rahman & Singh, 2019).”
- Transfer of heavy metals through terrestrial food webs: a review (2015, background): “Thus, most plants exclude excess bioavailable metals at their roots by binding them to organic acids or ligands or storing them within vacuoles where they cannot interfere with important physiological processes (Hossain et al. 2012; Gall and Rajakaruna 2013).”
- Biota as toxic metal indicators (2014, background): “In contrast, PCs are a family of enzymatically synthesized cysteine-rich peptides (Hossain et al. 2012).”
- Tomato tolerance to abiotic stress: a review of most often engineered target sequences (2017, background): “It also takes part in reducing hydrogen peroxide content (Hossain et al. 2012; Noctor et al. 2012).”
- Cross Protection by Cold-shock to Salinity and Drought Stress-induced Oxidative Stress in Mustard ( Brassica campestris L.) Seedlings (2013, methodology): “…production of ROS by interfering with different plant physiological and metabolic processes such as inactivation of the antioxidant defense system (Hoque et al., 2010, 2012; Hossain et al., 2012a) and interfering with vital plant physiological processes such as photosynthesis (Saito et al., 2010).”
- Engineering plants for heavy metal stress tolerance (2018, neutral): “When released into the environment, they may occur as free cations (such as Zn2+), cations bound to organics (such as Cu2+) and oxyanions (such as MoO4) and radioactive isotopes (such as 238U, 137Cs, 239Pt, 90Sr) (Hossain et al. 2012).”
- Heavy Metal Stress and Some Mechanisms of Plant Defense Response (2015, background): “HMs at toxic levels hamper normal plant functioning and act as an impediment to metabolic processes in a variety of ways, including disturbance or displacement of building blocks of protein structure, which arises from the formation of bonds betweenHMs and sulfhydryl groups [12], hindering functiona”
- Hemin-mediated alleviation of zinc, lead and chromium toxicity is associated with elevated photosynthesis, antioxidative capacity; suppressed metal uptake and oxidative stress in rice seedlings (2017, background): “05 1 3 1 3 the conversion of superoxide union to H2O2, APX and GR belong to the ascorbate–glutathione cycle and also play vital roles in eliminating H2O2 (Apel and Hirt 2004; Hossain et al. 2012).”