Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

By M. Rescigno, M. Urbano, B. Valzasina, M. Francolini, G. Rotta, R. Bonasio, F. Granucci, J. Kraehenbuhl, P. Ricciardi-Castagnoli. Nature Immunology, 2001

2,682 citations recorded by the source corpus.

Subfields: Management of Technology and Innovation, Organizational Behavior and Human Resource Management, Strategy and Management

View Paper: https://www.semanticscholar.org/paper/2f9eaae36d300a69b96cccd4eb2e0ac8ac7a9018

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Citations in the corpus

• Pathological bacterial translocation in liver cirrhosis. (2014, background): “198 Journal of Hepatology 201 microbes [6]; lamina propria DCs compromise two different subsets: CD103CX3CR1 DCs (inducing development of regulatory T cells) and CD103 CX3CR1 DCs (with features of macrophages, promoting TNF-production and development of Th1/Th17 T cells) (2) through interaction with”
• Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection (2012, background): “OMV-Associated PSA Induces Foxp3 and IL-10 from CD4 T Cells Themucosal immune system constitutively surveys the intestinal environment and DCs sample intestinal contents to coordinate T cell reactions (Rescigno et al., 2001).”
• TLR Signaling in the Gut in Health and Disease1 (2005, background): “Interdigitated among the intestinal epithelial cells are dendritic cells that sample the luminal contents and may present Ags to T cells present in the lamina propria and lymphoid follicles (1).”
• Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells (2006, background): “Furthermore, DCs in the LP might directly contribute to antigen uptake by extending dendrites through the epithelium, thereby sampling luminal antigens (13).”
• Monocyte-mediated defense against microbial pathogens. (2008, background): “Intraepithelial CD11c+ (65) and CD11b+CD8α− (66) DCs express tight junction proteins that interact with epithelial cell tight junctions, thereby allowing dendrites to pass between intestinal epithelial cells without disrupting the integrity of the barrier.”
• The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system (2014, neutral): “observed that lamina propria DC can extend dendrites between the epithelial cells and sample luminal antigen, this mechanism has been the favored model of intestinal antigen retrieval (83, 84).”
• The gut flora as a forgotten organ (2006, background): “Third, intestinal dendritic cells themselves have a pivotal immunosensory role and can directly sample gut contents by either entering or extending dendrites between surface enterocytes without disrupting tight junctions (Rescigno et al, 2001).”
• Interaction between the gut microbiome and mucosal immune system (2017, background): “DCs have the ability to continuously pass antigens through the barrier to mucosal-associated lymphoid tissue or to drain lymph nodes [35].”