Drosophila alpha/beta mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning.

By Dinghui Yu, D. Akalal, Ronald L. Davis. 2006

132 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “…our results indicate that circuits in the α lobe play key roles in long-term aversive and appetitive memory (Figure 10) (Pascual and Preat, 2001; Isabel et al., 2004; Yu et al., 2006; Blum et al., 2009; Sejourne et al., 2011; Cervantes-Sandoval et al., 2013; Pai et al., 2013; Placais et al., 2013).”
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability (2012, background): “Considering the importance of the vertical lobes in olfactory learning [8,9,39,40,41,42], MB-MV1 neuron might act together with MB-V1 neuron during memory acquisition.”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “While odor-evoked calcium signals increase in KC axons (Akalal et al., 2010, 2011; Boto et al., 2014; Tomchik and Davis, 2009; Wang et al., 2008; Yu et al., 2006, but see Zhang and Roman, 2013), signals in MBONs decrease in some cases (Owald et al., 2015; Séjourné et al., 2011) and increase in…”
Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation (2013, background): “LTM formation requires the transcription factor, CREB, and the N-methyl-D-aspartate (NMDA) receptor in many animals, includingDrosophila (12, 14, 26).”
Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila (2015, result): “Such an idea is consistent with several prior reports of aversive memory traces that are specific to the vertical a-branch of the mushroom body (Yu et al., 2005, 2006; Cervantes-Sandoval and Davis, 2012).”
Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation (2012, unknown): “The αβ neurons are critical for retrieval (McGuire et al., 2001; Dubnau et al., 2001), especially of long-term memory (Yu et al., 2006; Krashes and Waddell, 2008; Trannoy et al., 2011).”
Eight Different Types of Dopaminergic Neurons Innervate the Drosophila Mushroom Body Neuropil: Anatomical and Physiological Heterogeneity (2009, unknown): “In behavioral conditioning experiments, only forward pairing leads to associative memory (Tully and Quinn, 1985; Yu et al., 2006).”
A connectome of a learning and memory center in the adult Drosophila brain (2017, methodology): “We have densely reconstructed the connectome of the a lobe of the adult Drosophila MB, a region essential for long-term associative memory (Pascual and Préat, 2001; Pai et al., 2013; Yu et al., 2006; Séjourné et al., 2011; Akalal et al., 2011; Blum et al., 2009; Trannoy et al., 2011).”
Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila (2008, methodology): “A recent live-imaging study provided additional evidence that consolidated aversive LTM is represented in MB neurons (Yu et al., 2006).”
A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body (2011, unknown): “These data led us to propose that reverberant activity in a recurrent MB a0b0-to-DPM neuron circuit is required to hold labile memory and for consolidation to LTM within ab neurons [5, 9, 23, 24], where output is critical for retrieval of LTM [9, 23, 24].”
Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila (2013, unknown): “…g in short-term memory, for a0b0 after training for memory consolidation, and for ab in later memory retrieval, with the ab requirement becoming more pro- nounced as time passes (Zars et al., 2000; Yu et al., 2006; Krashes et al., 2007; Blum et al., 2009; Trannoy et al., 2011; Qin et al., 2012).”
A neural circuit mechanism integrating motivational state with memory expression in Drosophila (2009, background): “424 Cell 139, 416–427, October 16, 2009 ª2009 Elsevier Inc. Preat, 2001; Yu et al., 2005, 2006), other DA neurons in PPL1 that innervate the a lobe (like those labeled in MBGAL80;krasavietz, Figures 5C and S4) may provide reinforcement.”