Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors

By C. Kosinski, V. Li, Annie S Y Chan, Ji Zhang, Coral Ho, W. Tsui, T. Chan, R. Mifflin, D. Powell, S. Yuen and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

604 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/2f025a2609cea289f6b5e764f9cdb6865808b9ca

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Pathology and Forensic Medicine

Citations in the corpus

Eph-ephrin bidirectional signaling in physiology and disease. (2008, background): “It will be important to also examine the role of the EphA/ ephrin-A system in intestinal homeostasis because uneven mRNA expression along the crypts of the colon has also been reported for several EphA receptors and ephrin-A1 (Kosinski et al., 2007).”
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011, methodology): “Analysis of Mouse Signatures in Human Colon Crypt Top and Bottom Compartments We used the GSE6894 dataset (Kosinski et al., 2007), which contains expression profiles of microdissected human colon crypt top and bottom compartments (n = 9 pairs from different mucosa samples).”
Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors (2019, background): “programmed cell death, and are shed and eliminated with the faeces [4].”
The Consensus Molecular Subtypes of Colorectal Cancer (2015, methodology): “is supported by grants from the Dutch Cancer Society (UVA2011-4969, UVA2014-7245), Worldwide Cancer Research (14-1164), the Maag Lever Darm Stichting (MLDS-CDG 14-03) and the European Research Council (ERG-StG 638193).”
The intestinal crypt, a prototype stem cell compartment. (2013, background): “BMP-2 and -4 ligands are expressed in the mesenchyme of villi (Haramis et al., 2004), whereas BMP inhibitors are expressed in the mesenchyme around crypts (Kosinski et al., 2007).”
Wnt signaling in development and tissue homeostasis (2018, background): “Studies on the expression of Wnt target genes have identified a Wnt signaling gradient, with highest expression in the base of the crypt, particularly in the crypt base columnar cells (CBCs) (Kosinski et al., 2007; Van der Flier et al., 2007).”
Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value (2013, methodology): “Each molecular subtype was further characterized according to (i) GEP of NT counterparts from our dataset; (ii) previously published supervised signatures based on intestinal stem cell phenotype [24,25], BRAF mutation [26], and serrated CRC phenotype [27], as described in Text S1; (iii) cancer-relev”
Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential (2015, background): “Results Generating a Specific Marker of Skeletal Stem Cells To select a specific MSC marker in the bone and intestine, we considered human geneexpression arrays from bone marrow, intestine, and peritumoral mesenchyme (Delorme et al., 2009; Kosinski et al., 2007; Sneddon et al., 2006).”
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. (2009, background): “Human OLFM4 is enriched in human colon crypts (Kosinski et al., 2007).”