Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems.

By Wei Xiang, J. Kong, Songcang Chen, Li-ping Cao, Guilin Qiao, Wei Zheng, Wenhua Liu, Xinmin Li, D. Gardner, Y. Li. American Journal of Physiology. Endocrinology and Metabolism, 2005

611 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/d1e7aac658c3a062b5beeea7c156e0ca8e649c66

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Edward L. Giovannucci
2. E. Rimm
3. B. Hollis
4. M. F. Holick

In Pathology and Forensic Medicine

1. Edward L. Giovannucci
2. E. Rimm
3. S. Pilz
4. B. Boehm
5. U. Seelhorst
6. B. Wellnitz
7. H. Dobnig
8. Winfried März

Citations in the corpus

• Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “A VDRE has been identified in the promoter of the renin gene, and direct inhibition of renin expression by 1,25(OH)2D has been confirmed in vitro (586) and in vivo (121, 587).”
• Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. (2013, background): “, 2002), cardiac hypertrophy (Xiang et al., 2005), altered heart function (Tishkoff et al.”
• Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. (2008, methodology): “Vitamin D Deficiency and Heart Failure J Clin Endocrinol Metab, October 2008, 93(10):3927–3935”
• 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. (2008, background): “Disruption of the vitamin D receptor gene leads to elevated renin production, cardiac hypertrophy, and elevated blood pressure in mice.(28) In a randomized controlled trial (RCT)(29) of either UV-B or UV-A administered through tanning booths, UV-B, which increased 25(OH)D levels by 162%, was effecti”
• Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options. (2011, background): “netically modified mice lacking either the VDR (56,57) or”
• Vitamin D and cardiovascular disease. (2014, background): “In addition, the expression of type 1 natiuretic peptide receptor-A, an inhibitor of RAS and myocardial hypertrophy, is increased by 1,25(OH) 2 D.(63) The rate and magnitude of cardiomyocyte sarcomere contraction is modulated by 1,25(OH) 2 D via interaction with caveolin-3 in t-tubules.”
• Molecular Mechanisms of Vitamin D Action (2012, background): “More directly with respect to 1,25D and heart disease, the three relevant cell types, namely, endothelial, smooth muscle, and cardiac myocyte, all express VDR; and knockout of the receptor in mice elicits left ventricular hypertrophy and fibrosis [75].”
• 25-hydroxyvitamin D levels and the risk of mortality in the general population. (2008, background): “Vitamin D receptor knockout mice experience cardiac myocyte hypertrophy.(2) Activated vitamin D has antiproliferative properties.”
• Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. (2008, neutral): “001 Parathyroid hormone level, median (IQR), pg/mL 34 (26-46) 30 (23-40) 28 (21-36) 25 (19-33) .”