Molecular pathways to neurodegeneration

By E. Bossy‐Wetzel, R. Schwarzenbacher, S. Lipton. Nature Medicine, 2004

757 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/2e5b74876ebfb8762fec867755c2e10f3991eb5a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Youle
2. J. Martinou
3. Li-Huei Tsai
4. D. Sinclair
5. I. Dalle-Donne
6. G. Perkins
7. Olivier Bodenreider
8. A. Milzani

In Neurology

1. I. Dalle-Donne
2. Olivier Bodenreider
3. A. Milzani
4. R. Rossi
5. R. Youle
6. R. Colombo
7. S. Lipton
8. E. Verdin

In Physiology

1. D. Sinclair
2. Joseph A. Baur
3. I. Dalle-Donne
4. Li-Huei Tsai
5. A. Milzani
6. R. Rossi
7. R. Youle
8. P. Puigserver

Citations in the corpus

• Role of nrf2 in oxidative stress and toxicity. (2013, background): “A role of oxidative stress in neurodegenerative pathology is well recognized (2, 3, 168).”
• Advancing translational research with the Semantic Web (2007, background): “Increasingly, researchers recognize that Ad, PD, and HD share various features at the clinical [13], neural [14-17], cellular [18-20], and molecular levels [21,22].”
• Protein carbonylation, cellular dysfunction, and disease progression (2006, background): “Proteasomal dysfunction occurs in neurodegenerative disorders [66, 80, 84–86] and, consistently, the observation of ubiquitinated-protein inclusion bodies in neurons is one of the hallmarks of neurodegeneration [66, 85, 87, 88].”
• SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis (2007, background): “…neurodegenera- tion raises the possibility of developing a class of therapeutic interventions that treat a variety of neurological disorders by activating the body’s own defenses against age-related dete- rioration and cell death (Bossy-Wetzel et al, 2004; Forman et al, 2004; Selkoe, 2004).”
• Genetics of Alzheimer Disease (2010, neutral): “Amyloid precursor protein is also endocytosed from the cell surface and processed in the endosomal lysosomal pathway.(66,67) Amyloid precursor protein and its by-product Ab have been found to be translocated inside mitochondria and implicated in mitochondrial dysfunction.”
• Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons (2006, methodology): “That mitochondria become injured in the pathogenesis of neurodegenerative disorders is well documented (Beal, 2000; Bossy-Wetzel et al, 2004a).”