mTOR: a pharmacologic target for autophagy regulation.

By Young Chul Kim, K. Guan. Journal of Clinical Investigation, 2015

1,854 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b20f571b58a1e86f1c5ff6516c7447fd0f592614

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Molecular Biology

Citations in the corpus

Mechanisms (2019, neutral): “…(mTOR) signaling pathway [30]. mTOR is a serine/threonine kinase that actively participates in crucial biological processes, including gene transcription, protein translation, and ribosome synthesis, and exerts significant influence on cellular growth, apoptosis, autophagy, and metabolism [31].”
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions (2022, background): “Usually, mTOR limits autophagy by inhibiting phosphorylation of the Atg1/ULK1 protease complex.(149) During ischemic stroke, mTOR interacts with multiple signaling pathway components that regulate autophagy,(150) including PI3K/ Akt, AMPK, and MAPK.”
Autophagy and Tumor Metabolism (2017, background): “While most tissues have low levels of basal autophagy, it is significantly stimulated by the stressed state – the most well studied is starvation and this is tightly regulated by the mTOR and AMP kinase pathways (Kim and Guan, 2015; Mihaylova and Shaw, 2011; Neufeld, 2010).”
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages (2019, background): “Consistent with previous data that increased AMP kinase activity inhibits mTOR signaling and induces autophagy (Kelly and O’Neill, 2015; Shimobayashi and Hall, 2016), we found increased LC3 and increased bacterial clearance as a marker of effective autophagy in butyrate differentiated macrophages (K”
Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates (2015, background): “Next, we examined components of the Beclin1/Vps34 complex, which lies directly downstream of the ULK1 complex in autophagy initiation (Kim and Guan, 2015).”
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “Autophagy inducers can be classified into two main groups; those acting via mTORdependent or mTOR-independent targets. mTOR inhibitors are either ATP competitive 21 inhibitors (e.g. Torin1 and related compounds) or non-ATP competitive inhibitors (e.g. rapamycin and rapalogs) (Kim and Guan, 2015).”
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “154,155 The induction of autophagy through inhibition of mTORC1 has been well studied in yeast and drosophila models.”
The Roles of Autophagy in Cancer (2018, background): “mTOR consists of two complexes, mTORC1 and mTORC2, each of which exhibits distinct functions and localization [23,24,25].”