The multifaceted mismatch-repair system

By J. Jiricny. Nature reviews. Molecular cell biology, 2006

1,352 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/2de14d52a3dc2e6c06f7ed8464878dc589d437a8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Stephen P. Jackson
2. J. Bartek
3. M. Foiani
4. Dana Branzei
5. Stephen J. Elledge
6. Stephen B. Gruber
7. Alberto Ciccia
8. Eduardo Vilar

In Molecular Biology

1. Stephen P. Jackson
2. J. Bartek
3. Stephen J. Elledge
4. Dana Branzei
5. Alberto Ciccia
6. M. Foiani
7. Stephen B. Gruber
8. Eduardo Vilar

In Pathology and Forensic Medicine

1. J. Bartek
2. Stephen P. Jackson
3. Stephen B. Gruber
4. Alberto Ciccia
5. Dana Branzei
6. M. Foiani
7. Stephen J. Elledge
8. Eduardo Vilar

Citations in the corpus

• Microsatellite instability in colorectal cancer—the stable evidence (2010, background): “Insertions or deletions in microsatellites located in DNA coding regions generate frameshift mutations, which can lead to protein truncations”
• Mechanisms of DNA damage, repair and mutagenesis (2017, neutral): “Typical substrates for the MMR pathway are base mismatches that have arisen during replication and the insertion-deletion loops (IDLs) within repetitive DNA sequences that have resulted from strand slippage events [Errol C. Friedberg, 2005; Jiricny, 2006].”
• Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. (2011, neutral): “Finally, DNA synthesis must be resumed later by a replicative polymerase that first needs to be reloaded on DNA template.”
• PCNA, the maestro of the replication fork. (2007, neutral): “Mismatch repair (MMR) (Jiricny, 2006) corrects basebase mismatches and small insertion/deletion loops generated during faulty replication.”
• The DNA-damage response in human biology and disease (2009, background): “In mismatch repair, detection of mis-matches and insertion/deletion loops triggers a single-strand incision that is then acted upon by nuclease, polymerase and ligase enzymes 13 .”
• Regulation of DNA repair throughout the cell cycle (2008, background): “Base–base mismatches and small insertion and/or deletion loops that are generated by faulty replication are corrected by the mismatch repair (MMR) pathway, which functions mainly during S phas”
• The DNA Damage Response: Making it safe to play with knives (2010, background): “Mispaired DNA bases are replaced with correct bases by mismatch repair (MMR), and small chemical alterations of DNA bases are repaired by base excision repair (BER) through excision of the damaged base (Jiricny, 2006; Lindahl and Barnes, 2000).”