m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

By Shay Geula, S. Moshitch-Moshkovitz, D. Dominissini, A. Mansour, N. Kol, M. Salmon-Divon, Vera Hershkovitz, Eyal Peer, Nofar Mor, Y. Manor and 21 more. Science, 2015

1,464 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2db355f222fc6b05df2e36033d1b1d24acb799ab

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In Molecular Biology

1. Chuan He
2. Samie R. Jaffrey
3. P. He
4. S. Zaccara
5. Kate D. Meyer
6. Hailing Shi
7. Jiangbo W
8. Jianzhao Liu

Citations in the corpus

• A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation (2015, background): “Finally, a METTL3 knockout was recently described (Geula et al. 2015) in naïve pluripotent stem cells that”
• Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA (2016, background): “METTL3 KO led to decreased m(6)A modification of NANOG mRNA, increased NANOG mRNA stability, and decreased ESC differentiation (29, 34).”
• Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases (2016, neutral): “…and erasers has been linked to problems in self-renewal of stem cells, circadian clock and developmental defects, obesity, synaptic signaling, and cancers (Ben-Haim et al., 2015; Chen et al., 2015; Fustin et al., 2013; Geula et al., 2015; Peng et al., 2016; Wang et al., 2014a; Zheng et al., 2013).”
• Rethinking m6A Readers, Writers, and Erasers (2017, background): “Genetic deletion of METTL3 in plants, yeast, and mammalian cells leads to complete or near-complete loss of m6A in polyadenylated RNA (Agarwala et al. 2012, Geula et al. 2015, Zhong et al. 2008).”
• m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells (2017, methodology): “RNA modifications have been implicated in embryonic stem cell maintenance and differentiation (Batista et al., 2014; Wang et al., 2014; Geula et al., 2015), circadian rhythm modification (Fustin et al., 2013), heat shock response (Zhou et al., 2015), meiotic progression (Schwartz et al., 2013), and…”
• RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation (2015, background): “Mammals METTL3, METTL14 WTAP METTL3 and METTL14 regulate stem cell differentiation and reprogramming (Batista et al. 2014; Wang et al. 2014b; Geula et al. 2015).”
• METTL3 promotes translation in human cancer cells (2016, background): “These methylation marks can be dynamically regulated and m6A patterns can vary between cell types (Geula et al., 2015; Meyer et al., 2012).”
• Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism (2018, background): “Depletion of METTL14 causes a block in embryonic stem cell self-renewal and differentiation, embryonic developmental defects, and impaired gametogenesis in various organisms.(55,69,75) METTL14 and METTL3 participate in neurogenesis by modulating cell-cycle progression of cortical neural progenitor c”
• Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation (2017, background): “…decreases self-renewal of primed mouse embryonic stem cells (mESCs) (Wang et al., 2014a), whereas Mettl3 knockout naïve mESCs exhibit improved self-renewal and impaired differentiation, due to dysregulated decay of m6A-tagged transcripts, such as Nanog (Batista et al., 2014; Geula et al., 2015).”