RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

By Y. Yue, Jianzhao Liu, Chuan He. Genes & Development, 2015

845 citations recorded by the source corpus.

N6-methyladenosine (m6A) is the most prevalent internal modification that occurs in the messenger RNA (mRNA) of most eukaryotes. In this review, Yue et al. summarize recent progress in the study of the m6A mRNA methylation machineries across eukaryotes and discuss their newly uncovered roles in post-transcriptional gene expression regulation.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a120e1daf7bac78fe1da25949491a440ce0c2d1e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Chuan He
2. Hailing Shi
3. Zhike Lu
4. Quan Zou
5. Leyi Wei
6. Samie R. Jaffrey
7. P. He
8. S. Zaccara

Citations in the corpus

• Methylation multiplicity and its clinical values in cancer (2021, neutral): “29).”
• m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells (2017, background): “While m6A methyltransferases and demethylases act as its writers and erasers, respectively, m6A readers selectively bind to m6A-containing RNA to mediate downstream effects (Yue et al., 2015).”
• METTL3 promotes translation in human cancer cells (2016, neutral): “…and stem cell self-renewal and differentiation (Batista et al., 2014; Chen et al., 2015; Fustin et al., 2013; Geula et al., 2015; Iles et al., 2013; Lin and Gregory, 2014; Wang et al., 2014c; Zhao et al., 2014; Zheng et al., 2013) (reviewed in Meyer and Jaffrey, 2014; Yue et al., 2015).”
• Gene2vec: gene subsequence embedding for prediction of mammalian N6-methyladenosine sites from mRNA (2018, background): “However, only ∼15%of all methylation Pu[G>A]m(6)AC[A/C/U] consensus motifs are m(6)A sites (Yue et al. 2015).”