Rethinking m6A Readers, Writers, and Erasers
By Kate D. Meyer, Samie R. Jaffrey. Annual Review of Cell and Developmental Biology, 2017
996 citations recorded by the source corpus.
In recent years, m6A has emerged as an abundant and dynamically regulated modification throughout the transcriptome. Recent technological advances have enabled the transcriptome-wide identification of m6A residues, which in turn has provided important insights into the biology and regulation of this pervasive regulatory mark. Also central to our current understanding of m6A are the discovery and characterization of m6A readers, writers, and erasers. Over the last few years, studies into the function of these proteins have led to important discoveries about the regulation and function of m6A. However, during this time our understanding of these proteins has also evolved considerably, sometimes leading to the reversal of early conceptions regarding the reading, writing and erasing of m6A. In this review, we summarize recent advances in m6A research, and we highlight how these new findings have reshaped our understanding of how m6A is regulated in the transcriptome.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/1d3014dc2a591022dd79ae2697929244d0669d50
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In Molecular Biology
Citations in the corpus
- Where, when and how: context-dependent functions of RNA methylation writers, readers, and erasers (2019, background): “There have been arguments that YTHDF1–3 target almost identical m6A sites in HEK cells, supporting a model that YTHDF1–3 are redundant in function in mammals (Meyer and Jaffrey, 2017).”
- YTH Domain: A Family of N6-methyladenosine (m6A) Readers (2018, background): “However, eIF4-independent translation initiation can occur in case of eIF4 loss of function or viral mRNA translation [60].”