Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

By Ying Yang, Phillip J Hsu, Yu-Sheng Chen, Yun-Gui Yang. Cell Research, 2018

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N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m6A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

Subfields: Electrical and Electronic Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d59ec5b48b3b102110ec25d74b34b1e6a7e7ec7b