Functional significance of the perforin/granzyme cell death pathway

By J. Trapani, M. Smyth. Nature reviews. Immunology, 2002

1,339 citations recorded by the source corpus.

Subfields: Hematology, Infectious Diseases, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/2d7e5185e9f400a51cc9ad3e0144cb7653bed6c7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. J. Massagué
2. Dori A. Thomas
3. Susan A. Elmore
4. H. Beere
5. M. Smyth
6. J. Trapani
7. Y. Hayakawa

In Infectious Diseases

1. Dori A. Thomas
2. J. Massagué
3. Susan A. Elmore
4. H. Beere
5. M. Smyth

In Public Health, Environmental and Occupational Health

1. Dori A. Thomas
2. J. Massagué
3. Susan A. Elmore
4. H. Beere
5. M. Smyth

Citations in the corpus

• `The stress of dying': the role of heat shock proteins in the regulation of apoptosis (2004, background): “Once released by cytotoxic T lymphocytes (CTLs) or natural killer (NK) cells into the target cell, granzyme B can directly cleave pro-caspase-3 or Bid to induce apoptosis (Barry and Bleackley, 2002; Pinkoski and Green, 2002; Trapani and Smyth, 2002).”
• CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity1 (2006, background): “, IFN- ) (4), secretion of cytotoxic granules (5), and expression of TNF superfamily death-inducing ligands (6) that effectively control virus infection and tumor initiation and spread (7–9).”
• Apoptosis: A Review of Programmed Cell Death (2007, background): “…to exert their cytotoxic effects on tumor cells and virus-infected cells via a novel pathway that involves secretion of the transmembrane pore-forming molecule perforin with a subsequent exophytic release of cytoplasmic granules through the pore and into the target cell (Trapani and Smyth, 2002).”
• Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis (2019, background): “Perforin/granzymeinduced apoptosis is employed specifically by CD8+ cytotoxic T cells used by cytotoxic lymphocytes to eliminate virusinfected or transformed cells [59].”
• Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “NK cells share a common killing mechanism with CD8þ cytotoxic T lymphocytes, relying on directed exocytosis of secretory lysosomes that contain lytic proteins such as perforin, granzymes, and Fas ligand (2, 3).”
• TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance (2005, positive): “The mechanisms of GzmA-and GzmB-induced apoptosis, as defined by cleavage of their respective intracellular substrates, are quite distinct (Lieberman and Fan, 2003; Trapani and Smyth, 2002).”
• Perforin-mediated target-cell death and immune homeostasis (2006, background): “, and is crucial for the function of the other granule constituents that are involved in target-cell death, in particular the family of granzymes that are released with perforin following the formation of an immunological synaps”