Perforin-mediated target-cell death and immune homeostasis
By I. Voskoboinik, M. Smyth, J. Trapani. Nature reviews. Immunology, 2006
635 citations recorded by the source corpus.
Subfields: Hematology, Public Health, Environmental and Occupational Health, Speech and Hearing
View Paper: https://www.semanticscholar.org/paper/4c4e7a845019776c6213312c15cfd15e1e60fab8
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In Hematology
Citations in the corpus
- How Do Cytotoxic Lymphocytes Kill Cancer Cells? (2015, background): “The pore forming protein, PRF1 (16), along with GZMs, which are members of a family of serine proteases, are the dominant constituents of the (1)Department of Biochemistry, Molecular and Cell Biology, Fundaci on Instituto de Investigaci on Sanitaria Arag on (IIS Arag on)/University of Zaragoza, Zara”
- Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “Upon activation, NK cells mediate the tumor killing mainly by releasing cytotoxic perforin (Voskoboinik et al. 2006) and granzyme, eliminating tumor cells and also triggering apoptotic pathways in tumor cells through the production of TNF α or via direct cell – cell contact through activation of…”
- NK cells and cancer immunosurveillance (2008, background): “…are primarily viewed as cytotoxic lymphocytes; upon activation, NK cells exocytose cytotoxic granules containing perforin and various granzymes, leading to the perforation of target cells and subsequent apoptotic death induced by the permeated granzymes (Lieberman, 2003; Voskoboinik et al., 2006).”