The mitochondrial calcium uniporter is a highly selective ion channel

By Yuriy Kirichok, G. Krapivinsky, D. Clapham. Nature, 2004

1,472 citations recorded by the source corpus.

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Citations in the corpus

Shaping the calcium signature. (2009, background): “The principal pathway for [Ca]mit accumulation is the mitochondrial uniporter, a Ca2+-selective channel at the inner mitochondrial membrane that is neither ATP-dependent nor coupled to ion exchange (Kirichok et al., 2004).”
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. (2014, background): “One of these, the uniporter (231, 372, 450, 451), has low affinity but high capacity for transporting Ca(2) , whereas Ca(2) /2H and Ca(2) /2Na exchangers (60, 61, 75, 98, 136, 137) have much lower capacity.”
Structural and functional features and significance of the physical linkage between ER and mitochondria (2006, background): “The [Ca]m signal results from activation of the uniporter-mediated Ca2+ uptake that shows a relatively low Ca2+ affi nity (Kirichok et al., 2004; Nicholls, 2005).”
MICU1 is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake That Regulates Cell Survival (2012, neutral): “Furthermore, the open probability of the uniporter Ca2+ channel is nearly unity at normal ΔΨm (Kirichok et al., 2004).”
MAM (2009, background): “The importance of the MAM began to emerge when it was found that, after the agonist stimulation to the cell, mitochondria were able to uptake Ca2+ into their lumen directly from IP3 receptors at the MAM [24-26].”
Mitochondria in health and disease: perspectives on a new mitochondrial biology. (2004, background): “Very recently, patch clamp recordings from mitoplasts have revealed a Ca2þ selective inwardly rectifying channel/current in the inner mitochondrial membrane which has characteristics consistent with the properties of the uniporter (Kirichok et al., 2004), although the molecular identity of the chann”
Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface (2010, neutral): “Measurement of [Ca2+]ER-mt with Pericam Inserted into Interorganellar Linkers Activation of the mitochondrial Ca2+ uptake mechanism referred to as uniporter requires supramicromolar [Ca2+]c (Gunter and Pfeiffer, 1990; Kirichok et al., 2004).”
Calcium, ATP, and ROS: a mitochondrial love-hate triangle. (2004, background): “A recent patchclamp study suggests the that MCU is a highly selective (Kd 2 nM) Ca(2) channel (99), but attempts to define its molecular nature have been largely unsuccessful.”
Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. (2006, background): “Both the VDAC and the UP show Ca2+-dependent activation that is relevant for the homeostatic control of cytoplasmic [Ca2+] ([Ca]c) [1,3,4].”
Calcium and ROS: A mutual interplay (2015, background): “Patch clamp electrophysiology of isolated mitoplasts (mitochondria with the outer membrane removed) demonstrated that Ca2þ influx was mediated by a highly Ca2þ selective ion channel [84].”