Association of FOXO3A variation with human longevity confirmed in German centenarians

By Friederike Flachsbart, A. Caliebe, Rabea Kleindorp, H. Blanché, Huberta von Eller-Eberstein, S. Nikolaus, Stefan Schreiber, A. Nebel. Proceedings of the National Academy of Sciences of the United States of America, 2009

617 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/2ce629091a6edefbad6b76cea726e2dc15f223c9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Nicholas A. Bishop
2. Rute Martins
3. W. Link
4. Tao Lu
5. G. Lithgow
6. A. Brunet
7. B. Yankner
8. Hilmar Bading

In Molecular Biology

1. Dervis A M Salih
2. Atul J. Butte
3. Fred H. Gage
4. J. Gonçalves
5. T. Palmer
6. M. Hetzer
7. A. Brunet
8. N. Denko

In Physiology

1. Atul J. Butte
2. Nicholas A. Bishop
3. Rute Martins
4. Fred H. Gage
5. Dervis A M Salih
6. W. Link
7. Tao Lu
8. G. Lithgow

Citations in the corpus

• Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects (2015, positive): “For example, genetic polymorphisms within the FOXO3 gene have been associated with human longevity (Flachsbart et al., 2009; Willcox et al., 2008).”
• FoxO3 regulates neural stem cell homeostasis (2009, positive): “In humans, single-nucleotide polymorphisms in one of the four FoxO genes, FoxO3, have recently been associated with extreme longevity (Flachsbart et al., 2009; Willcox et al., 2008), raising the possibility that FoxO3 also regulates lifespan in mammals.”
• Neural mechanisms of ageing and cognitive decline (2010, background): “Polymorphisms in two IIS pathway genes, the IGF-1 receptor and the downstream FOXO3 transcription factor, have been associated with longevity and healthy ageing in human”
• Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “These results were confirmed in the German population (Flachsbart et al., 2009).”