Enterotypes in the landscape of gut microbial community composition

By P. Costea, F. Hildebrand, Manimozhiyan Arumugam, F. Bäckhed, Martin J. Blaser, Frederic D. Bushman, W. D. de Vos, S. Ehrlich, Claire M Fraser, M. Hattori and 19 more. Nature Microbiology, 2017

924 citations recorded by the source corpus.

Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept. This Perspective debates the concept of enterotypes and their use to characterize the gut microbiome, and provides a classifier and standardized methodology to aid cross-study comparisons.

Subfields: General Health Professions, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2ce08b06303ec30ae3e9d021378a9d178777369f

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In Molecular Biology

Citations in the corpus

Enterotypes of the human gut mycobiome (2022, methodology): “The fecal samples of ITS1 and ITS2 amplification were separately clustered into fungal enterotypes by using a partitioning around medoid (PAM) clustering method [75] as those previously described for bacterial enterotype discovery [13, 14].”
Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health (2020, background): “4 In line with this, the concept of entero-types paved the way for other efforts towards subject-specific therapies, exemplified by the two distinct strategies for weight loss proposed for either the Prevotella - enterotype or Bacteroides - enterotype, considering their different responses to NDCs.…”
Antibiotics as Major Disruptors of Gut Microbiota (2020, background): “The clinical implications of enterotypes have been the subject of several studies (Costea et al., 2018).”
The Human Gut Microbiome: From Association to Modulation. (2018, neutral): “…factor is probably the gut enterotype, although it is not clear 121 whether such community types follow external co-variates such as diet, transit time or 122 inflammation, or represent intrinsically different compositional optima with similar functionality, 123 or both (Costea et al., 2018).”