Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

By Sudha Singh, Alexander S. Davis, G. A. Taylor, V. Deretic. Science, 2006

976 citations recorded by the source corpus.

Subfields: Endocrinology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/2cc2d46f3a560a3558ecca63a11f768b93bdfd77

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. N. Mizushima
2. Beth Levine
3. D. Klionsky
4. V. Deretic
5. Herbert W. Virgin
6. J. Cox
7. R. Watson
8. P. Manzanillo

In Epidemiology

1. Beth Levine
2. N. Mizushima
3. I. Slaninová
4. D. Klionsky
5. Guido Kroemer
6. V. Deretic
7. Douglas R. Green
8. D. Rubinsztein

In Physiology

1. Beth Levine
2. N. Mizushima
3. Douglas R. Green
4. D. Klionsky
5. L. Galluzzi
6. D. Rubinsztein
7. V. Deretic
8. M. Komatsu

Citations in the corpus

• Macrophage defense mechanisms against intracellular bacteria (2015, background): “Infection-induced autophagy by IFN-c activation or by starvation requires activation of the small GTPase LRG47 (IRGM in humans) (76, 77).”
• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn’s disease (2008, background): “rs13361189 lies immediately upstream of IRGM , a gene previously shown to be essential for autophag”
• Common disorders are quantitative traits (2009, background): “Recently, GWA research has implicated autophagy as a previously unsuspected quantitative mechanism in CD pathogenesi”
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “The human IRG (IRGM) can eliminate mycobacteria through induction of autophagy (122), requiring IRGM expression in mitochondria (123).”
• Antimicrobial mechanisms of phagocytes and bacterial evasion strategies (2009, background): “and the activation of immunity-related p47 guanosine triphosphatase protei”
• Toll‐like receptors control autophagy (2008, background): “Toll-like receptors control autophagy”
• Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. (2007, background): “Induction of autophagy by starvation, rapamycin or LRG47 expression resulted in increased co-localization of the mycobacterial phagosomes with the autophagosomes, and reduced mycobacterial survival (Gutierrez et al., 2004; Singh et al., 2006).”
• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis (2007, background): “So far, the role of autophagy in innate immune recognition has been little studied, but several systems have been identified that show a potential role in host defens”
• Inflammation and cancer: An ancient link with novel potentials (2007, background): “tases (IRGM) plays a role in autophagy and reduces intracellular bacteria.(9) Single nucleotide polymorphism 313T>C in IRGM, an”
• Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions (2009, background): “The IRGM gene has been shown experimentally to eliminate intracellular Mycobacterium tuberculosis via autophagy [31].”