Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells

By V. Pasceri, J. Willerson, E. Yeh. Circulation, 2000

2,064 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/2caea8d6f73df1308343f4fbd1584264a47a1c20

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Peter Libby
2. P. Ridker
3. G. Hansson
4. S. Grundy
5. N. Rifai
6. J. Willerson
7. Nicola R. Sproston
8. J. Ashworth

In Immunology

1. Peter Libby
2. P. Ridker
3. G. Hansson
4. Erling Falk
5. Renu Virmani
6. S. Grundy
7. Frank O. Nestle
8. J. Krueger

In Oncology

1. P. Ridker
2. Peter Libby
3. G. Hansson
4. N. Rifai
5. B. K. Pedersen

Citations in the corpus

• Role of C-Reactive Protein at Sites of Inflammation and Infection (2018, background): “The pentameric protein is synthesized primarily in liver hepa tocytes but has also been reported to be synthesized in other cell types such as smooth muscle cells (28), macrophages (29), endothelial cells (30), lymphocytes, and adipocytes (31).”
• The Vascular Endothelium and Human Diseases (2013, background): “CRP decreases eNOS-mediated NO production by decreasing the stability of eNOS mRNA (69).”
• Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. (2004, background): “C-reactive protein has been shown to promote secretion of inflammatory mediators by vascular endothelium (20, 21 ) and opsonizes low-density lipoprotein for uptake by mac-”
• Low grade chronic inflammation in women with polycystic ovarian syndrome. (2001, background): “Our finding of increased CRP in PCOS is also relevant because recent data suggest that CRP, rather than being simply a marker of low grade chronic inflammation, may be directly involved in the atherogenic process by promoting endothelial dysfunction and complement activation ( 24 , 25).”
• Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. (2004, background): “CRP causes expression of endothelial adhesion molecules (63) and chemoattractants (64) and mediates LDL uptake by macrophages (65).”
• Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. (2010, background): “In addition, in cell culture, both CRP and serum amyloid A promote a number of proinflammatory cellular effects, including monocyte recruitment, activation of complement, and stimulation of cellular adhesion molecule and cytokine expression (Pasceri et al., 2000; Woollard et al., 2002; Han et al., 2”