The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.

By B. Harfe, Michael T. McManus, J. Mansfield, E. Hornstein, C. Tabin. Proceedings of the National Academy of Sciences of the United States of America, 2005

703 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2c923a353861177b09004198faa677f9558894b6

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Citations in the corpus

The Host Shapes the Gut Microbiota via Fecal microRNA (2016, positive): “FloxP sites on either side of the Dicer1 gene (Dicer1) result in the Cre-expressing cell-specific deletion of miRNAs (Harfe et al., 2005).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “likely, the lack of miRNAs as well, leads to impaired morphogenesis of the lung epithelium (104), the vertebrate limb (103), and the skin (6, 299).”
MicroRNA signatures in human cancers (2006, background): “The conditional knockout Dicer mouse has developmental defects, including lung epithelium abnormalitie”
MicroRNA functions in animal development and human disease (2005, background): “And, finally, in M. musculus, removal of Dicer in the limb mesoderm leads to a dramatic programmed cell death in the developing limb (Harfe et al., 2005).”
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (2008, methodology): “RNA secondary structures were predicted using RNAfold (Hofacker et al. 1994), unless otherwise noted. miRNA annotations were taken from miRBase version 10.0 (Griffiths-Jones et al. 2008), and mm8 genome coordinates were obtained using BLAT (Kent 2002), unless otherwise noted.”
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. (2008, positive): “This may or may not relate to other experimental systems in which increased cell death was observed upon conditional Dicer ablation (Cobb et al., 2005; Fukagawa et al., 2004; Harfe et al., 2005; Muljo et al., 2005).”
The neuronal microRNA system (2006, methodology): “The role of miRNAs in the apoptosis that accompanies neuronal development was probably foreshadowed by studies of the mouse limb bud that employed a conditional dicer knockout that was targeted to discrete regions of the limb mesoder”
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. (2007, methodology): “Generation of Dicer Conditional Null or miR-1-2-Null Mice Dicer flox/flox mice (Harfe et al., 2005) and Nkx2.”
MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles (2013, positive): “By affecting gene expression, miRNAs are likely involved in most biological processes [8-12].”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “In mice, conditional knockout of Dicer leads to the formation of abnormally small limbs, mainly due to massive cell death [14].”