Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

By O. Gavrilova, M. Reitman, C. Deng, A. Kimmel, C. Londos. Proceedings of the National Academy of Sciences of the United States of America, 2001

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Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores (2011, background): “In perilipin-1-deficient mice, perilipin-2 is the major LD coating protein in adipocytes [112].”
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores (2009, background): “Data from perilipin knockout mice are consistent with this model as such mice show increased basal and decreased stimulated lipolysis [56,57].”
Regulation of energy metabolism by long-chain fatty acids. (2014, background): “Perilipin KO mice exhibited decreased lipid storage due to increased basal lipolysis, as well as submaximal lipolytic response when stimulated, demonstrating a critical role of perilipin in regulation of lipolysis in adipose [183].”
Opinion: Lipid droplets: a unified view of a dynamic organelle (2006, background): “, whereas perilipin-null mice are lean and resistant to diet-induced obesit”
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “Human (236, 237) and animal (238) forms of lipodystrophy are characterized by selective loss of sc and visceral fat and are associated with a number of metabolic abnormalities, such as dyslipidemia, hyperglycemia, and insulin resistance.”