Dynamics of mitochondrial morphology in healthy cells and during apoptosis

By M. Karbowski, R. Youle. Cell Death and Differentiation, 2003

793 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2c363317f12c6a190ab49be4c5f9a1be04672b08

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

In Molecular Biology

Citations in the corpus

The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. (2005, positive): “(2004) manipulated the GTPases Drp1 (dyc namin-related protein 1) and Opa1 (optic atrophy), o which alter the morphology and distribution of mitot chondria by controlling mitochondrial fission and fusion l (Karbowski and Youle, 2003).”
Calcium, ATP, and ROS: a mitochondrial love-hate triangle. (2004, background): “However, even in normal cells (95) mitochondria display dynamic tubular networks undergoing constant fission, fusion, and cytoskeletal trafficking (8, 9, 138).”
A hyperfused mitochondrial state achieved at G1–S regulates cyclin E buildup and entry into S phase (2009, background): “Besides leading to cyclin E buildup and controlling G1–S progression, the giant, voluminous mitochondrial network at G1–S could serve other cellular functions such as efficient homogenization and complementation of mitochondrial DNA in the continuous matrix (1); enhanced mitochondrial ATP to compens”
The role of mitochondria in apoptosis. (2008, background): “controlled through mitochondrial fusion and fission machinery by mitochondria-shaping proteins (6, 7), including the large GTPases mitofusins, Mfn1 and Mfn2 (8) and optic atrophy pro-”
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, background): “mitochondrial networks, and this dynamic morphology is essential for normal mitochondrial and cellular functions (Karbowski and Youle, 2003; Okamoto and Shaw, 2005; Chan, 2006; McBride et al., 2006; Cerveny et al., 2007b; Hoppins et al., 2007; Benard and Karbowski, 2009).”
Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity (2004, background): “Mitochondria are very dynamic and change shape depending on cell environment, physiology, developmental stage and pathologic condition (Yaffe, 1999; Jensen et al., 2000; Griparic and van der Bliek, 2001; Shaw and Nunnari, 2002; Karbowski and Youle, 2003; Scott et al., 2003; Westermann, 2003; Chen an”