Human metabolic phenotype diversity and its association with diet and blood pressure

By Edward C. Holmes, R. Loo, J. Stamler, M. Bictash, I. Yap, Q. Chan, T. Ebbels, M. Iorio, Ian J. Brown, K. Veselkov and 6 more. Nature, 2008

1,042 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/2bf7f56b3f2041c5b0e852ae7aaf9bd554368e52

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Citations in the corpus

Phenomics: the next challenge (2010, background): “In humans, metabolome-wide association studies have identified metabolites reliably associated with phenotypes such as blood pressur”
Systems medicine: the future of medical genomics and healthcare (2009, background): “lomics surveys of urine [222,223], and they will increasingly”
Genetic determinants of the gut microbiome in UK Twins (2016, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Europe (Holmes et al., 2008).”
Intestinal microbiota in human health and disease: the impact of probiotics (2011, background): “A variety of systemic diseases such as hypertension (Holmes et al. 2008) and diabetes (Dumas et al.”
The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation (2016, background): “Dysbiosis of the microbiome has been associated with a large number of health problems and causally implicated in metabolic, immunological, and developmental disorders, as well as susceptibility to development of infectious diseases [4–11].”
Worlds within worlds: evolution of the vertebrate gut microbiota (2008, background): “Furthermore, urinary levels of gut microorganism–host co-metabolites , such as hippurate, phenylacetylglutamine and methylamines, differentiate present-day East Asian and Western population”
Human oral, gut, and plaque microbiota in patients with atherosclerosis (2010, background): “Dental disease has been associated with elevated risk of myocardial infarction (14), and metabolic activity of the gut microbiota was recently shown to relate to blood pressure (16).”
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation (2013, background): “Intriguingly, a previous study of human populations living in Asia (China and Japan) and Europe (United Kingdom) showed a direct association between urinary formate, a SCFA generated by microbial fermentation of dietary polysaccharides, and blood pressure (18); the signaling pathways and mechanisms ”
An atlas of genetic influences on human blood metabolites (2014, background): “31 Fructose, mannose and galactose (4)”
Gut microbiome-host interactions in health and disease (2011, methodology): “This analytical strategy has now been successfully applied to disease states such as hypertension [8], ischemic heart disease [56], diabetes [57] and obesity [58] as part of large-scale clinical studies.”