Essential Role for Sphingosine Kinases in Neural and Vascular Development

By K. Mizugishi, T. Yamashita, A. Olivera, G. Miller, Sarah Spiegel, R. Proia. Molecular and Cellular Biology, 2005

756 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2b9a664e5b9d4ff0ea5ef685fe5aea770f0a5ba6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. LM Obeid
2. Yusuf A. Hannun
3. B. Ogretmen
4. J. Cyster
5. Susan R. Schwab
6. J. Chun
7. S. Milstien
8. Sarah Spiegel

In Molecular Biology

1. Sarah Spiegel
2. Yusuf A. Hannun
3. B. Ogretmen
4. LM Obeid
5. S. Milstien
6. Susan R. Schwab
7. J. Cyster
8. J. Chun

Citations in the corpus

• Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis (2010, background): “In particular, S1P1 expressed on lymphocytes regulates the normal egress of lymphocytes from lymphoid tissues, whereas S1P receptors expressed in the CNS have been shown to modulate functions relevant to MS neuropathologic features, including neurogenesis, neural function, and migration (as describe”
• An overview of sphingolipid metabolism: from synthesis to breakdown (2010, background): “Crossing of SphK1 −/− and SphK2 −/− mice revealed that complete absence of SK activity, and therefore S1P, results in embryonic lethality due to improper neural and vascular development [135].”
• Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis (2010, background): “, and genetic deletion of either the S1P 1 receptor or SPHKs (to eliminate S1P ) caused severe disturbance of neurogenesis and neural tube closure, resulting in increased apoptosis in the developing brai”
• Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “Like S1P 1 -deficient mice, fetal Sphk1 −/− Sphk2 −/− mice die midgestation because of defects in vascular maturatio”
• Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “Additionally, in endothelial and smooth muscle cells, SK1/S1P/S1PR signaling also has several specific effects on the promotion of vascular development and angiogenesis (Argraves et al., 2004; Chae et al., 2004; Mizugishi et al., 2005).”
• THE ALLIANCE OF SPHINGOSINE-1-PHOSPHATE AND ITS RECEPTORS IN IMMUNITY (2008, background): “More specifically, deletion of the genes that encode both kinases is embryonic lethal and results in embryos lacking S1”
• Principles of bioactive lipid signalling: lessons from sphingolipids (2008, background): “The combined knockout of SK1 and SK2 also recapitulated this phenotyp”
• “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “Despite the fact that either SphK1 or SphK2 single knockout mice develop and reproduce normally, the double knock-out completely eliminates S1P and is embryonically lethal because of severely disturbed neurogenesis, including neural tube closure, and angiogenesis (Mizugishi et al., 2005).”