Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming.

By A. Martín-Fontecha, L. Thomsen, S. Brett, C. Gerard, M. Lipp, A. Lanzavecchia, F. Sallusto. Nature Immunology, 2004

756 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2b7d9573dcd21a37ba353944c477328ec83fb441

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Citations in the corpus

CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - a target for novel cancer therapy (2017, background): “[34, 35] All three variants of CXCR3 are expressed on T cells, where CXCL9, -10, -11 collectively stimulate the loss of surface CXCR3 expression and elicit directional migration responses to the focal sites.”
Inflammation and aging: signaling pathways and intervention therapies (2023, background): “Also, the signs of reduced NK cell effector functions, such as decreased cytotoxicity, as well as lower expression of perforin and granzyme and reduced secretion of IFN-α and IFN-γ but more IL-1, IL-4, IL-6, IL-8, IL-10, and TNF-α are identified.(67,68) Besides, with increasing donor age, the freque”
Dendritic cells prime natural killer cells by trans-presenting interleukin 15. (2007, methodology): “the recruitment of NK cells to LN after local application of TLR-stimulated BMDCs (Martin-Fontecha et al., 2004).”
CXCR3 in T cell function (2011, background): “IFNγ from NK cells has also been shown drive CD4+ Th1 cell differentiation in the lymph node, which may also apply Th1 responses in inflamed tissues [49].”
NK cells and cancer immunosurveillance (2008, background): “In fact, NK cells are considered as the major source of IFN-g in vivo, and recent studies demonstrated that NK-derived IFN-g is crucial in priming T helper 1 (Th1)-biased T-cell responses (Mocikat et al., 2003; Martin-Fontecha et al., 2004).”
The chemokine system in innate immunity. (2015, background): “For example, CXCR3-mediated NK cell migration guides IFN-g-secreting NK cells into the LN where they help prime the LN for a Th1 response (Martin-Fontecha et al. 2004).”