CXCR3 in T cell function

By J. Groom, A. Luster. Experimental Cell Research, 2011

915 citations recorded by the source corpus.

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells following activation and preferentially remains highly expressed on Th1-type CD4+ T cells and effector CD8+ T cells. CXCR3 is activated by three interferon-inducible ligands CXCL9 (MIG), CXCL10 (IP-10) and CXCL11 (I-TAC). Early studies demonstrated a role for CXCR3 in the trafficking of Th1 and CD8 T cells to peripheral sites of Th1-type inflammation and the establishment on Th1 amplification loop mediated by IFNγ and the IFNγ-inducible CXCR3 ligands. More recent studies have also suggested that CXCR3 plays a role in the migration of T cells in the microenvironment of the peripheral tissue and lymphoid compartment, facilitating the interaction of T cells with antigen presenting cells leading to the generation of effector and memory cells.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/af4bcf64f456b5ff7aa034b1eae788499f14c340

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In Immunology

1. S. Spranger
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5. Jing Wang

In Oncology

1. S. Spranger
2. T. Gajewski
3. Jing Wang
4. D. Dai
5. B. Horton

Citations in the corpus

• Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy (2017, result): “Consistent with the literature (Groom and Luster, 2011; Mikucki et al., 2015), we observed that CD3 T cells isolated from BP tumors expressed CXCR3 (Figure 6A).”
• Targeting DNA damage response promotes anti-tumor immunity through STING-mediated T-cell activation in small cell lung cancer (2019, background): “Because CXCL10 and CCL5 are key mediators for the chemotaxis of CD8+ T lymphocytes, and CXCL10 and CCL5 overexpression is associated with the presence of CD8+ T lymphocytes in melanoma and gastric and colorectal cancers (34, 35), we next investigated the previously unexplored link between DDR target”