Histone lysine demethylases: emerging roles in development, physiology and disease

By Yang Shi. Nature reviews genetics, 2007

602 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2b6c0e012966c1d7ac987d4e9954061703fbdb16

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Citations in the corpus

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. (2009, background): “In addition, recent studies have implicated LSD1 in several growth-promoting pathways and have linked LSD1 to certain high-risk tumors (Forneris et al., 2008; Kahl et al., 2006; Shi, 2007; Wang et al., 2007a).”
Covalent modifications of histones during development and disease pathogenesis (2007, background): “Histone lysine methylation is also reversible, being carried out by two families of enzymes, amine oxidases such as LSD1 and hydroxylases of the JmjC famil”
Epigenetic modifications and human disease (2010, background): “, GASC1, LSD1, JmjC and UTRX) have also been shown to be upregulated or amplified in several cancers, including prostate cancer and squamous cell carcinoma”
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. (2010, background): “In this regard, Vc is a cofactor in reactions driven by dioxygenases including collagen prolyl hydroxylases, HIF (hypoxia-inducible factor) prolyl hydroxylases, and histone demethylases (Shi, 2007), and it is interesting to consider that Vc might influence reprogramming by increasing the activity of”
Epigenetic Modifications as Therapeutic Targets (2010, background): “Cancer cells are characterized by dysregulation of histone methyltransferases and histone demethylases, overexpression of histone deacetylases (HDACs), and a global reduction in levels of histone acetylatio”