Localization of Long-Term Memory Within the Drosophila Mushroom Body

By Alberto Pascual, T. Préat. 2001

374 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Immunology

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “Previous studies and our results indicate that circuits in the α lobe play key roles in long-term aversive and appetitive memory (Figure 10) (Pascual and Preat, 2001; Isabel et al., 2004; Yu et al., 2006; Blum et al., 2009; Sejourne et al., 2011; Cervantes-Sandoval et al., 2013; Pai et al., 2013;…”
Olfactory representations by Drosophila mushroom body neurons. (2008, background): “Previous work suggests that the three classes play different roles in memory formation, possibly because they connect to different postsynaptic targets (Akalal et al. 2006; Krashes et al. 2007; Pascual and Preat 2001; Zars et al. 2000).”
Drosophila strategies to study psychiatric disorders. (2013, background): “In adult flies, dFMR1 mutants show an increase in projections and more extensive arborisation in parts of the circadian clock circuitry [45,110] as well as a midline-crossing defect in the !-lobe of the mushroom body, a large neuropil in the central brain that plays a crucial role in both short- and”
Neuronal assemblies of the Drosophila mushroom body (2008, background): “Structural mutants of the MB disrupt the establishment of short- and long-term memories (Heisenberg et al., 1985; Pascual and Preat, 2001).”
Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila (2011, methodology): “For aversive training, flies were conditioned by an odor paired with electric shocks and subsequent exposure to a second odor in the absence of shock, as describe”
Evolution of insect mushroom bodies: old clues, new insights (2005, background): “…of the fruit fly Drosophila melanogaster as a key molecular genetic model system, the insect mushroom bodies have become an important source of information on the molecular basis and cellular localization of learning and memory (Zars et al., 2000; Pascual and Préat, 2001; McGuire et al., 2003).”
Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, positive): “Graphical Abstract Introduction The Drosophila mushroom bodies (MB) play an important role in olfactory learning and memory formation (de Belle and Heisenberg, 1994; McGuire et al., 2001; Pascual and Preat, 2001).”
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability (2012, background): “Considering the importance of the vertical lobes in olfactory learning [8,9,39,40,41,42], MB-MV1 neuron might act together with MB-V1 neuron during memory acquisition.”
Olfactory memory formation in Drosophila: from molecular to systems neuroscience. (2005, background): “A recent report claimed that long-term memory formation occurs within the α and α′ collaterals of the α/β and α′/β ′ MB neurons, respectively (Pascual & Preat 2001), and if true, offers an intriguing cellbiological dimension to Drosophila long-term memory formation, with long-term memories forming…”
The Long-Term Memory Trace Formed in the Drosophilaα/β Mushroom Body Neurons is abolished in Long-Term Memory Mutants (2011, neutral): “For example, a single cycle of conditioning produces robust short-term memory (STM) that decays over a period of 1 d (Tully et al., 1994; Beck et al., 2000; Pascual and Préat, 2001).”
A Late-Phase, Long-Term Memory Trace Forms in the γ Neurons of Drosophila Mushroom Bodies after Olfactory Classical Conditioning (2010, background): “For instance, a single cycle of conditioning generates robust short-term memory that decays over the period of 1 d (Tully et al., 1994; Beck et al., 2000; Pascual and Préat, 2001).”
A connectome of a learning and memory center in the adult Drosophila brain (2017, methodology): “We have densely reconstructed the connectome of the a lobe of the adult Drosophila MB, a region essential for long-term associative memory (Pascual and Préat, 2001; Pai et al., 2013; Yu et al., 2006; Séjourné et al., 2011; Akalal et al., 2011; Blum et al., 2009; Trannoy et al., 2011).”