Alveolar progenitor and stem cells in lung development, renewal and cancer
By T. Desai, D. Brownfield, M. Krasnow. Nature, 2014
962 citations recorded by the source corpus.
Subfields: Molecular Biology, Pulmonary and Respiratory Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/2b05e561d76d73becfe8789a83e349fb75f7ef24
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In Molecular Biology
- Hans Clevers
- James M. Wells
- Stephen R. Quake
- Irving L. Weissman
- J. Rock
- H. Chapman
- E. Morrisey
- B. Hogan
In Pulmonary and Respiratory Medicine
In Surgery
Citations in the corpus
- Variation in cancer risk among tissues can be explained by the number of stem cell divisions (2015, neutral): “Finally, the stem cell division rate for lung tissue (specifically the alveoli) has been estimated to be 7% per year (103).”
- Modeling Development and Disease with Organoids. (2016, background): “Indeed, sorted type II cells remained proliferative in short-term culture and could generate type I cells (Desai et al., 2014; Treutlein et al., 2014).”
- A molecular cell atlas of the human lung from single cell RNA sequencing (2019, background): “The 58 identified cell populations included 15 epithelial (clusters 1-15), 9 endothelial (16-24), 9 stromal (25-33), and 25 immune (34-58) populations, greater than the number of classical cell types in each compartment (11 epithelial, 5 endothelial, 7 stromal, 20 immune, and 2 neuronal cell types) ”
- Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities (2022, background): “AT1 cells mediate gas exchange, and AT2 cells secrete surfactants to maintain alveolar morphology.(76) During airway differentiation, inhibition of the Wnt/β-catenin pathway contributes to the rapid directional differentiation of pluripotent stem cells into proximal airway epithelial cells, while ac”
- Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function (2014, methodology): “, 2011a) and by hyperoxia (Desai et al., 2014), the rate of differentiation of lineage labeled AEC2s into AEC1s is much higher.”
- In vitro generation of human pluripotent stem cell derived lung organoids (2015, background): “Two groups have defined a bipotent progenitor population in the embryonic/ neonatal lung that gives rise to both AECI and AECII cells (Desai et al., 2014; Treutlein et al., 2014).”