Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

By A. Simonsen, R. Cumming, A. Brech, P. Isakson, D. Schubert, K. Finley. Autophagy, 2008

701 citations recorded by the source corpus.

Subfields: Aging, Epidemiology

View Paper: https://www.semanticscholar.org/paper/2a8ff7bf4f8536a595114ebfd7186807413776da

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Guido Kroemer
2. Linda Partridge
3. Guillermo Mariño
4. D. Rubinsztein

In Epidemiology

1. Guido Kroemer
2. Guillermo Mariño
3. D. Rubinsztein
4. Fiona M Menzies
5. P. Saftig
6. E. Eskelinen
7. Angeleen Fleming
8. Linda Partridge

Citations in the corpus

• Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “Similarly, pan-neuronal over-expression of Atg8a (Simonsen et al., 2008) or AMPK (Ulgherait et al., 2014) in Drosophila resulted in extended lifespan.”
• Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster (2010, background): “However, under stress, such as lack of nutrients or growth factors, and in hypoxia, cap-independent translation increases (Sonenberg and Hinnebusch, 2009), allowing a switch to synthesis of other proteins, such as growth factors and heat shock proteins (Baird et al., 2006), which enables the cell…”
• Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “basal levels of autophagy in the nervous system of adult Drosophila enhances longevity of theflies [128].”
• Autophagy and aging. (2011, background): “Similarly, deficient expression in Atg1, Atg8, and Sestrin1 (which is also required for basic autophagy) reduces the life span of the fruit fly Drosophila melanogaster (Lee et al., 2010a; Simonsen et al., 2008).”
• Molecular definitions of autophagy and related processes (2017, neutral): “Aggrephagy has been described in a variety of model organisms, including yeast (Lu et al , 2014b), worms (Jia et al , 2007; Lu et al , 2013), flies (Simonsen et al , 2008), plants (Toyooka et al , 2006), and mammals (Bjorkoy et al , 2005; Hara et al , 2006; Komatsu et al , 2006).”