Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures

By C. Nelson, M. Vanduijn, J. Inman, D. Fletcher, Mina J. Bissell. Science, 2006

619 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/2a5764691cf76938e96604b40a021abeb55a606a

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Citations in the corpus

Mechanical compression drives cancer cells toward invasive phenotype (2011, background): “A shift in stress balance due to interactions with other cells (32, 36, 42) or cell distortion as a cell actively adapts to its local matrix environment (7, 43) can initiate cytoskeletal rearrangement, proliferation, and morphogenesis (32, 33).”
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “For example, Nelson and co-workers identified a role for inhibitory morphogens that act in an autocrine manner to dictate the precise spatial location of sprouting in 3Dpatterned mm-scale epithelial tubes (Nelson et al., 2006).”
Three-dimensional bioprinting of thick vascularized tissues (2016, background): “T ability to manufacture human tissues that replicate the essential spatial (1), mechanochemical (2, 3), and temporal aspects of biological tissues (4) would enable myriad applications, including 3D cell culture (5), drug screening (6, 7), disease modeling (8), and tissue repair and regeneration (9,”
Balancing forces: architectural control of mechanotransduction (2011, neutral): “Furthermore, the position of epithelial cells in 3D engineered mammary epithelial tubules determines whether they undergo branching morphogenesis in response to EGF or hepatocyte growth factor (HGF), where branches are initiated exclusively from the ends of the tubules and not from the side”
Mechanical control of tissue and organ development (2010, background): “Tensional forces and ECM mechanics also contribute to epithelial cell differentiation and morphogenesis during mammary gland development (Alcaraz et al., 2008; Nelson et al., 2006).”
Micropatterning as a tool to decipher cell morphogenesis and functions (2010, background): “For example, homogeneous secretion of inhibitory morphogens in a tubule-like structure made of mammary epithelial cells promotes tubule elongation rather than broadening, and a curvature in the tubule favours outgrowth on the external side (Nelson et al., 2006).”
Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “Furthermore, cells at the sites of branching activate the promoter of the mesenchymal marker, vimentin, and express MMP3, an inducer of EMT [66].”
Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “[102] showed that tissue geometry dictates the position of the branches.”