Antioxidant and prooxidant properties of flavonoids.

By D. Prochazkova, I. Boušová, N. Wilhelmová. Fitoterapia, 2011

1,456 citations recorded by the source corpus.

The interest in possible health benefits of flavonoids has increased owing to their potent antioxidant and free radical scavenging activities observed in vitro. Nevertheless, the antioxidant efficacy of flavonoids in vivo is less documented and their prooxidant properties have been actually described in vivo. Due to their prooxidant properties, they are able to cause oxidative damage by reacting with various biomolecules, such as lipids, proteins and DNA. Hence, the aim of this review is to discuss both the antioxidant and prooxidant effects of flavonoids.

Subfields: Biochemistry, Endocrinology, Diabetes and Metabolism, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/2a15822cbf86ac590bfc811999e6e6ae8162c5e5

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Citations in the corpus

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “The beneficial health properties of flavonoids have been attributed to their ability to scavenge ROS and suppress oxidative stress (Prochazkova et al. 2011).”
Polyphenols in Monogastric Nutrition – A Review (2017, background): “…polyphenols restrict the generation of ROS in the cells by inhibiting the activity of pro-oxidant enzymes (membrane-associated NAD(P)H oxidase, xanthine oxidase, and protein kinase C) which participate in the intracellular electron transport chain (Procházková et al, 2011; Fraga et al., 2010).”
Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target? (2019, background): “Flavonoids have been shown to possess many antioxidant properties, and some of the mechanisms include: direct scavenging of ROS, activation of antioxidant enzymes, metal chelating activity, mitigation of α-tocopherol radicals, inhibition of oxidases, reduction of oxidative stress caused by NO, incre”
Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid (2016, background): “[13] Flavonoids are also act as prooxidants and promoting the oxidation of other compounds.”
Important Flavonoids and Their Role as a Therapeutic Agent (2020, background): “The antioxidant potential of flavonoids is more robust than vitamin C and vitamin E [81].”
Oxidative Stress: Harms and Benefits for Human Health (2017, background): “Under conditions like high concentrations, high pH, and the presence of redox-active metals, phenolic compounds can acquire a prooxidant behavior [157, 158], mainly based on the generation of an aroxyl radical or a labile complex with a metal cation exerting redox activity.”
A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. (2013, background): “The latter are defined as chemicals that induce oxidative stress, usually through the formation of reactive species or by inhibiting antioxidant systems (Puglia and Powell, 1984).”