Do astrocytes really exocytose neurotransmitters?
By N. Hamilton, David Attwell. Nature Reviews Neuroscience, 2010
657 citations recorded by the source corpus.
Subfields: Biochemistry, Biological Psychiatry, Cellular and Molecular Neuroscience
View Paper: https://www.semanticscholar.org/paper/e23e921ab27bfd15fa26af6a380039f2f30508a7
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Citations in the corpus
- Cell biology of astrocyte-synapse interactions (2017, positive): “In agreement with this possibility, injection of human glial progenitors, which give rise to astrocytes and oligodendrocyte-lineage cells, into the mouse brain significantly altered mouse brain connectivity and enhanced behavior (Han et al., 2013).”
- Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse (2015, neutral): “They obtained transcriptome profiles of purified human CNS cell types and discovered two distinct stages of human astrocyte development.”
- Neuronal calcium signaling: function and dysfunction (2014, background): “ATP released during synaptic transmission activates astrocytic receptors, which in turn initiate Ca2+ signals and propagate Ca2+ waves in the astroglial networks through the activation of metabotropic P2Y receptors (P2YRs) and the diffusion of inositol 1,4,5 tris–phosphate through the gap-junctions ”
- Physiology of Astroglia. (2018, neutral): “Numerous studies, in vitro (in astroglial-neuronal cocultures), in situ, and in vivo have addressed this matter; many sets of data have been generated, and heated debates ensued (55, 632, 1205, 1526).”
- Interactions between the immune and nervous systems in pain (2010, background): “This leads to the release from astrocytes of a battery of mediators, including glutamate, D -serine and ATP, which in turn modulate neuronal activit”
- Glutamate as a neurotransmitter in the healthy brain (2014, background): “Neverthe- less, it seems likely that also mature astrocytes in situ may release glutamate (Malarkey and Parpura 2008; Nederg- aard and Verkhratsky 2012; Wang et al. 2013), but exo- cytosis of vesicles similar to those in nerve terminals is questionable (Hamilton and Attwell 2010).”