Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

By L. A. Herndon, Peter J. Schmeissner, Justyna M. Dudaronek, Paula A. Brown, Kristin M. Listner, Y. Sakano, Marie-Christine Paupard, David H. Hall, Monica Driscoll. Nature, 2002

1,195 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/29de30c9d05fb4021ff3f5ecb15999cf10730a99

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Citations in the corpus

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. (2004, methodology): “Moreover, a lipofuscin-like fluorescent pigment that accumulates in an age-dependent manner in the intestine (Garigan et al. 2002; Herndon et al. 2002) accumulates at a faster rate in aak-2 mutants than in wild-type animals (Fig.”
Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans (2010, background): “As the integrity of muscle tissue degenerates sharply with age [51,52], intracellular localization of age-dependent aggregates becomes challenging.”
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. (2003, background): “…for muscle and neuronal cells are intriguing given previous observations that preservation of the nervous system is important in the regulation of longevity and that muscle cells of C. elegans are also particularly susceptible to aging-related decline (Wolkow et al., 2000; Herndon et al., 2002).”
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. (2003, background): “elegans, aging involves pleiotropic changes that vary among individuals, and mutations that influence lifespan may affect aging of some tissues more than others (Garigan et al. 2002; Herndon et al. 2002).”
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. (2003, background): “How-stress-response genes (McElwee et al., 2003; Murphy ever, with the exception of the nervous system, whichet al., 2003; Yu and Larsen, 2001) that contribute to daf-2 does not show signs of age (Herndon et al. 2002), withinlongevity (Hsu et al., 2003; Murphy et al., 2003).”
Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 (2010, background): “elegans ages, locomotion rates on solid media and in liquid decline [43–46], and the severity of impairment is roughly correlated with the degree of muscle deterioration that bears striking cell biological similarity to human sarcopenia [43,47].”
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis During Aging (2010, background): “…of Cell 143, 813–825, November 24, 2010 ª2010 Elsevier Inc. 813 814 Cell 143, 813–825, November 24, 2010 ª2010 Elsevier Inc. aging in other tissues (Herndon et al., 2002), and reducedmuscle strength is associated with an increased risk in developing Alzheimer’s and Parkinson’s diseases (Boyle…”
Insights into the ageing mind: a view from cognitive neuroscience (2004, background): “Work with a popular animal model of ageing, the nematode Caenorhabditis elegans , has found gradual age-related degeneration of muscle tissue, but preservation in the nervous system, thereby providing hope that the cognitive effects of ageing are not inevitabl”
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, neutral): “elegans (Herndon et al., 2002), sarcomeres of aging CST knockdown nematodes appeared more disorganized, containing discontinuities and bends in muscle fibers, when compared to control nematodes (Figure 6G and data not shown).”
The plasticity of aging: insights from long-lived mutants. (2005, background): “…are resistant o many age-related diseases, including Huntington’s isease in a C. elegans disease model (Morley et al., 002), sarcopenia in worms (Herndon et al., 2002), heart ailure in Drosophila (Wessells et al., 2004), and cancer n rodents (Bielschowsky, 1961; Ramsey et al., 2002). hus this…”