ROS, stress‐activated kinases and stress signaling in cancer

By M. Benhar, D. Engelberg, Alexander Levitzki. EMBO Reports, 2002

622 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/29a6ca3d83a33a90d135fc82d440dba3c7d906f3

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Citations in the corpus

Iron metabolism and toxicity. (2005, background): “It is clear that iron overload disrupts the redox balance of the cell and generates chronic oxidative stress, which modulates signaling networks related to malignant transformation (Benhar et al., 2002).”
Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “They also participate in blood pressure control [177], are mediators in the biosynthesis of prostaglandins [178], function in embryonic development [179], and act as signalingmolecules within the individual cell and among cells during their lifespan [180].”
Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “However, under oxidative stress conditions, excessive ROS can damage cellular proteins, lipids, and DNA, giving rise to fatal lesions in cells that, in turn, contribute to many human diseases, including cancer (14, 29, 67, 90, 314).”
Reactive oxygen species in tumor progression. (2005, background): “1887 ROS also activate members of the MAPK family such as p38, JNK, and ERKs (80, 81, 112-115).”
Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “…factor erythroid 2-related factor 2 (NF-E2/rf2 or Nrf2) (Kensler, Wakabayashi, and Biswal 2007), mitogen-activated protein (MAP) kinase/AP-1 (Benhar, Engelberg, and Levitzki 2002), and NF-kB pathways (Pantano et al. 2006) as well as hypoxia-inducible transcription factor 1 a (HIF-1a; Rankin…”
Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification (2002, background): “They also participate in blood pressure control (264); are important mediators in the biosynthesis of other molecules, such as prostaglandins (145); function in embryonic development (223); and act as signaling molecules within the individual cell and among cells during their life spans (26).”