NOD-LRR proteins: role in host-microbial interactions and inflammatory disease.

By N. Inohara, M. Chamaillard, C. McDonald, G. Núñez. Annual Review of Biochemistry, 2005

1,041 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology, Parasitology

View Paper: https://www.semanticscholar.org/paper/289ea6bf8e4bc55fc6e8428b2554bfefc6ff56e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. Rafi Ahmed
2. Bali Pulendran
3. Shizuo Akira
4. G. Núñez
5. O. Takeuchi
6. B. B. Finlay
7. N. Inohara

In Immunology

1. Shizuo Akira
2. O. Takeuchi
3. M. Karin
4. R. Medzhitov
5. G. Núñez
6. Bali Pulendran
7. T. Kanneganti
8. Rafi Ahmed

In Parasitology

1. Rafi Ahmed
2. Bali Pulendran

Citations in the corpus

• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “Four subfamilies are defined for the presence of N-terminal CARD, PYD, BIR, and acidic domains (18, 19).”
• Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. (2006, background): “Nod1 and Nod2 are leucine rich repeat (LRR) intracellular proteins that function analogously to TLRs to detect peptidoglycan inside host cells (Philpott and Girardin, 2004; Inohara et al., 2005).”
• RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “Nod-like receptors (NLRs), which have a characteristic C-terminal LRR and internal nucleotide-binding domain (NBD), are known to detect cytoplasmic PAMPs, leading to the activation of cytokine expression including IL-1b (4, 5).”
• A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation (2008, background): “Members of the nucleotide-binding domain-like receptor (NLR) protein family are found in both mammals and plants (Inohara et al, 2005; Fritz et al, 2006).”
• Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “Interestingly, mutations in the gene encoding NOD2 have been associated with increased frequencies of inflammatory bowel disease, suggesting a role for these proteins in regulating inflammation (Inohara et al., 2005).”
• The immunology of sepsis (2008, background): “NOD2 and a related protein, NALP3, that resides within the inflammasome, can recognize the inflammatory component of peptidoglycan, comprising a subunit known as muramyl dipeptide (MDP) [24].”