A Road Map for Those Who Don't Know JAK-STAT
By D. Aaronson, C. Horvath. Science, 2002
1,417 citations recorded by the source corpus.
Subfields: Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/28650f8722f858c4b1ad1aa22727124c2fa4d7df
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Kenneth S. Kosik
- Anna M. Krichevsky
- M. Sofroniew
- T. Graeber
- K. Sonntag
- G. Feng
- Ole Isacson
- K. Takeda
In Pharmacology
- K. Sonntag
- Kenneth S. Kosik
- Ole Isacson
- K. Takeda
- Anna M. Krichevsky
- D. Harrison
- J. Rawlings
- Shizuo Akira
Citations in the corpus
- Sustained axon regeneration induced by co-deletion of PTEN and SOCS3 (2011, methodology): “, we tested the specific involvement of the transcription factor STAT3, a major target of the JAK/STAT pathwa”
- Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury (2013, background): “…effects of various cytokines and growth factors, including interleukin 6, ciliary neurotrophic factor, and LIF, which are released by various cell types at sites of CNS injuries and play roles in regulating inflammatory responses of various kinds (Hirano et al., 2000; Aaronson and Horvath, 2002).”
- STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury (2008, background): “The STAT3 is a member of the Jak-STAT signaling family that transduces signals for many cytokines and growth factors (Aaronson and Horvath, 2002).”
- Immunomodulatory functions of type I interferons (2012, background): “Other STAT complexes that do not recruit IRF9, including STAT1 homodimers, bind to IFNγ-activated site (GAS) enhancer elements in the promoters of ISG”
- Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression (2017, positive): “All of these molecules are known to be involved in the JAK-STAT signaling pathway downstream of the interferon gamma receptor (Aaronson and Horvath, 2002).”
- Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis (2006, positive): “In addition, multiple studies demonstrated that STAT3 phosphorylation at Tyr705 leads to its activation and nuclear translocation with subsequent binding to target mRNAs [ 35 , 36].”
- The JAK/STAT signaling pathway (2004, positive): “Mechanistically, JAK/STAT signaling is relatively simple, with only a few principal components (for reviews, see Aaronson and Horvath, 2002; Heinrich et al., 2003; Kisseleva et al., 2002; O’Shea et al., 2002).”