Self-organizing optic-cup morphogenesis in three-dimensional culture

By Mototsugu Eiraku, Nozomu Takata, H. Ishibashi, Masako Kawada, Eriko Sakakura, Satoru Okuda, K. Sekiguchi, T. Adachi, Y. Sasai. Nature, 2011

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Modeling Development and Disease with Organoids. (2016, positive): “To mimic this process in vitro (Eiraku et al., 2011), Sasai and colleagues again generated floating embryoid bodies from re-aggregated murine ES cells in growth factor-free medium to generate neuroectoderm.”
Organogenesis in a dish: Modeling development and disease using organoid technologies (2014, background): “Skeletal muscle Embryonic chick leg skeletal muscle (76) Mesoangioblasts from human iPSCs (106) Anchored contracting skeletal muscle in 3D matrix derived from myoblast progenitors (107) Bone Skeletal bone of chick embryonic leg (77) Osteoblasts from mESCs (108) and hESCs (109) Bone spheroids from hu”
Self-formation of optic cups and storable stratified neural retina from human ESCs. (2012, methodology): “Our previous study demonstrated that the NR eversion (from apically concave to convex) in mESC culture requires the presence of RPE and the hinge (Eiraku et al., 2012) and does not spontaneously occur in NR epithelium isolated before invagination (Figure 4D, top; Eiraku et al., 2011).”
Stem Cell Organoid Engineering (2016, positive): “Recently introduced stem cell-derived organoids have been used to mimic aspects of human organogenesis and have achieved notable morphological similarities to their native counterparts (Eiraku et al., 2011; Lancaster et al., 2013; Stange et al., 2009).”