Engineering plants with increased levels of the antioxidant chlorogenic acid

By R. Niggeweg, A. Michael, Cathie Martin. Nature Biotechnology, 2004

738 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/284a34bfff2010e42eca0308c94725c2af6aed0d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. L. Cisneros-Zevallos
2. T. Umezawa
3. C. Chapple

In Molecular Biology

1. Zeng‐Yu Wang
2. Alisdair R. Fernie
3. C. Chapple
4. Richard A. Dixon
5. C. Fu
6. Xirong Xiao
7. Fang Chen
8. J. Bouton

Citations in the corpus

• Comparative metabolomics and transcriptomics of plant response to Tomato yellow leaf curl virus infection in resistant and susceptible tomato cultivars (2014, background): “Accumulation of CGA together with the increased expression of the HCT, CCoAOMT1 and CAD genes (Fig.”
• Globe artichoke as a functional food (2010, neutral): “Enhancement of phenolic complement is presently pursued in various crops by genetic engineering [25].”
• Downregulation of Cinnamyl Alcohol Dehydrogenase (CAD) Leads to Improved Saccharification Efficiency in Switchgrass (2011, background): “Increasing the levels of chlorogenic acid has been pursued in food crops for their potential health benefit [49].”
• Mycorrhizal colonization impacts on phenolic content and antioxidant properties of artichoke leaves and flower heads two years after field transplant (2010, neutral): “New varieties of artichoke with higher polyphenolic content could be obtained by means of genetic engineering and breeding programs (Niggeweg et al. 2004).”
• The genetics of lignin biosynthesis: connecting genotype to phenotype. (2010, background): “This possibility has been called into question, however, by the low affinity of characterized HCTs for quinate (48, 75), as well as the subsequent identification of a paralog of HCT from tomato that is apparently dedicated to chlorogenic acid biosynthesis (85).”
• Identification of defence metabolites in tomato plants infected by the bacterial pathogen Pseudomonas syringae (2011, positive): “Hydroxycinnamoyl-CoA quinate:hydroxycinnamoyl transferase (HQT) has been found to be the crucial enzyme which enables the synthesis of CGA in tobacco and tomato plants (Hoffmann et al., 2003; Niggeweg et al., 2004).”
• Breeding for chlorogenic acid content in eggplant: interest and prospects. (2013, methodology): “This fact, together with its numerous bioactive properties potentially beneficial for human health, encourages the use of breeding approaches in order to increase its level in food crops (Niggeweg et al., 2004).”
• Cytology, biochemistry and molecular changes during coffee fruit development (2006, background): “, 2004), which increased the interest to study CGA pathways in plants (Hoffmann et al., 2003; Niggeweg et al., 2004), including coffee (Campa et al.”
• Chlorogenic acid synthesis in coffee : An analysis of CGA content and real-time RT-PCR expression of HCT, HQT, C3H1, and CCoAOMT1 genes during grain development in C. canephora (2007, methodology): “Over-expression of HQT in tomato was found to increase the CGA content up to 85% in leaves, while HQT silencing caused up to a 98% reduction of CGA in the leaves [11].”
• Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome (2017, background): “Chlorogenic acid can be found in foods and herbs such as apples [5–9], artichoke [10], betel [11], burdock [12], carrots [13–15], coffee beans [5,7–9,11], eggplants [5], eucommia [16], grapes [8], honeysuckle [7], kiwi fruit [9], pears [5], plums [5,6], potatoes [5,7,17,18], tea [8,11], tobacco leav”
• The cinnamate/monolignol pathway (2010, background): “tabacum and Lycopersicon esculentum (tomato) (Niggeweg et al. 2004).”
• Effect of nitrogen starvation on the phenolic metabolism and antioxidant properties of yarrow (Achillea collina Becker ex Rchb.) (2009, background): “…than by engineering plants with constitutively high metabolite level, for instance by overexpressing enzymes of a specific biosynthetic pathway (Niggeweg et al., 2004; Canter et al., 2005), growing plants in hydroponics, with appropriate manipulation of nutritional and environmental factors…”