L-arginine metabolism in myeloid cells controls T-lymphocyte functions.

By V. Bronte, P. Serafini, A. Mazzoni, D. Segal, Paola Zanovello. Trends in immunology, 2003

619 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/27c99d7a42f0538da1969d02223aeef9c57681ca

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Citations in the corpus

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment (2020, neutral): “(J), Genes specific for each cluster (HSP90AA1, CD274(PD-L1), CD177, MME(CD10), ARG1) visualized along the diffusion pseudotime (top) with the density of each cluster along the pseudotime (bottom) highlighting the proposed order of differentiation of the different neutrophil subsets. ll Article”
Immunity to fungal infections (2011, background): “Accumulating evidence indicates that cells of the myeloid lineage are capable of positive and negative regulation of T-cell functio”
The tumor microenvironment and its role in promoting tumor growth (2008, background): “MSC present in tumors constitutively express iNOS and arginase 1, an enzyme involved in metabolism of L-arginine, which also synergizes with iNOS to increase superoxide and NO production, blunting lymphocyte responses (Bronte et al., 2003; Ochoa et al., 2007; Tsai et al., 2007).”
Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. (2006, background): “Although Gr-1 immature myeloid cells from the spleens of tumorbearing mice have been shown to suppress the proliferation of CD4 and CD8 T cells (18, 46), the sorted Gr-1 single positive cells of Percoll fraction 2 did not suppress HA-mediated proliferation of CD4 (Fig.”
Helminth parasites – masters of regulation (2004, background): “Arginase is produced by AAMFs and may create a suppressive environment by depleting arginine from the surrounding environment (144).”
Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “In addition to cell surface markers, MDSC have been characterized by their content of suppressive molecules including arginase (10, 57, 58), iNOS (59), and other reactive oxygen species (58, 60), and have been classified as “neutrophil-like” or “monocyte-like” based on their nuclear morphology (38).”
The tumor microenvironment at a glance (2012, background): “Murine and human MDSCs inhibit CD8 T cell activation through the expression of nitric oxide synthase 2 (NOS2) and arginase (ARG1) (Bronte et al., 2003).”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “IL-1 -induced accumulation of MDSC was independent of host T cells, B cells, and NK cells, and the MDSC had increased levels of ROS and enhanced suppressive activity against CD4 and CD8 T cells relative to MDSC induced in less inflammatory environments.”
Regulation of immune responses by L-arginine metabolism (2005, background): “LPS, which is commonly referred to as a T H 1-cytokine inducer, can activate both ARG1 and NOS2 expression by the macrophages of rodents other than mic”