Neurons, numbers and the hippocampal network.

By D. Amaral, N. Ishizuka, B. Claiborne. 1990

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Citations in the corpus

Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity (2016, background): “The ratio of GCs to PP afferents is aligned with estimations of about 200,000 EC Layer II cells in the rat (Amaral et al., 1990), suggesting a ratio of 20 EC cells per 100 GCs.”
A putative role for neurogenesis in neuro-computational terms: inferences from a hippocampal model. (2009, unknown): “Since each neuron in the dentate gyrus is connected with approximately 15 neurons in CA3 in the real hippocampus (Amaral et al., 1990), each unit in CA3 received only 5 connections from the new neural group in DG 1⁄2ð300 15Þ 1000 in the model.”
A computational model of pattern separation efficiency in the dentate gyrus with implications in schizophrenia (2015, background): “The number of granule cells in the DG is approximately ﬁve times larger than the number of entorhinal cells (Amaral et al., 1990) where input pattern separation takes place (Bakker et al., 2008).”
A Spin Glass Model of Path Integration in Rat Medial Entorhinal Cortex (2006, background): “Amaral et al. (1990) estimated that there were 200,000 layer II entorhinal cortical cells that projected to the dentate gyrus (DG).”
Geometry and Structural Plasticity of Synaptic Connectivity (2002, background): “, 1987; (Amaral et al., 1990) (Shepherd and Harris, (Harris and Stevens, West et al.”
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. (2012, unknown): “…that, under these conditions, neither the greater number nor sparse activity of DG GCs compared to cells in the superficial layers of the EC (Amaral et al., 1990; Jung and McNaughton, 1993), on which most models are based, is sufficient for pattern separation of similar contexts or spaces.”
Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network (2006, unknown): “and ∼300,000 CA3 pyramidal neurons (per hippocampus; [4]), and as a single granule cell contacts ∼15 CA3 pyramidal neurons, a single CA3 pyramidal neuron on average receives input from ∼15×1,000,000/300,000=50 granule cells.”
Spatial representations of granule cells and mossy cells of the dentate gyrus (2017, background): “Granule cells, located in the densely packed granule cell layer (GCL), are by far the most numerous cell type in the DG (Amaral et al., 1990).”
Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory. (2003, background): “In CA3, each pyramidal cell is contacted by ca. 4% of the pyramidal cells of the same subfield (Amaral 1990), implying that most CA3 pyramidal cells are connected via 2–3 synaptic steps (Rolls & Treves 1998).”
Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas (2006, background): “In CA3, each pyramidal cell is contacted by 4% of the pyramidal cells of the same subfield (Amaral, 1990), implying that most CA3 pyramidal cells are connected via two or three synaptic steps (Rolls & Treves, 1998).”
Computational analysis of the role of the hippocampus in memory (1994, background): “proportion (about *h; Amaral et al., 1990) from the direct perforant path projections from entorhinal cortex.”