Multidrug-resistance efflux pumps ? not just for resistance

By L. Piddock. Nature Reviews Microbiology, 2006

1,570 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/27562ade75e6f896365651c5134d5b201de40de6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Z. Deng
2. J. Pagés
3. T. Foster
4. Gerard D. Wright
5. Jingjing Sun
6. Xian-Zhi Li
7. Andreas G. Tofarides
8. A. Yan

In Molecular Medicine

1. Xian-Zhi Li
2. H. Nikaido
3. J. Pagés
4. E. Dassa
5. C. Orelle
6. A. Davidson
7. Jue Chen
8. Z. Deng

In Pharmacology

1. H. Nikaido
2. Xian-Zhi Li
3. Z. Deng
4. J. Pagés
5. T. Foster
6. Gerard D. Wright
7. Jingjing Sun
8. Andreas G. Tofarides

Citations in the corpus

• Antibiotic resistance in Staphylococcus aureus. Current status and future prospects (2017, background): “The Tet efflux proteins exchange a proton for a tetracyclinemolecule against a concentration gradient (Piddock 2006).”
• Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence (2019, background): “Clinical resistance is usually the result of mutational events leading to increased pump expression or improved pump effectiveness (Piddock 2006a, b).”
• Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, background): “Moreover, these efflux pumps are involved in the QS-regulated expression of virulence determinants (68).”
• The antibiotic resistome: the nexus of chemical and genetic diversity (2007, background): “These pumps presumably function to provide the maximum flexibility to the organism so that it can exploit diverse environments, to promote pathogenicity, and to modulate cellular differentiation, such as the formation of biofilm”
• CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (2009, background): “Diagrama de transportadores de resistencia pertenecientes a las familias ABC, RND y MFS, todos ellos formando un complejo tripartito con TolC en bacterias gram-negativas (Piddock, 2006).”
• Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “Indeed, the drug efflux pumps can respond to a range of stimuli including stress signals, and they influence the colonization, pathogenesis or virulence, cell communications, biofilm formation and other fitness responses.([609-611]) These functions may well be the physiological functions of at least”
• The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria (2008, background): “Here, we focus on the influx of antibiotics, as the efflux has been extensively discussed in recent review”
• Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms (2009, background): “, cell-to-cell communication and pathogenicity) (193), besides their protective effects against antimicrobials.”
• Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems (2008, background): “Furthermore, some transporters are involved in pathogenicity and are suspected to export virulence factors important for colonization and infection of mammalian cells (363).”