Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis.
By J. Cools-Lartigue, J. Spicer, B. McDonald, S. Gowing, S. Chow, B. Giannias, F. Bourdeau, P. Kubes, L. Ferri. Journal of Clinical Investigation, 2013
1,238 citations recorded by the source corpus.
Subfields: Immunology, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/d11904226624a9c8e792338721742a7d2fd9e802
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In Immunology
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In Immunology and Allergy
Citations in the corpus
- Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “In recent years, the presence of NETs in the TME has been linked to cancer progression in animal models and cancer patients (Cools-Lartigue et al. 2013, 2014; Tohme et al. 2016), NETs are extracellular networks released by neutrophils — composed mostly of chromatin, proteases (such as elastase,…”
- Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016, background): “NETs that form intravascularly in response to infection can promote extravasation of disseminated cancer cells (5).”
- The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “Neutrophils could also potentially enhance MetSC settlement by producing neutrophil extracellular traps (NETs) (Casbon et al., 2015; Cools-Lartigue et al., 2013; Kitamura et al., 2015).”
- Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice (2018, positive): “NETs formed in response to systemic bacterial infection or after surgical stress promote cancer dissemination (19, 20).”
- EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “For example, neutrophil extracellular traps (NETs), which are formed from released DNA molecules, are designed to entangle pathogens during a response to infection but can also be deployed by neutrophils to capture tumor cells in the circulation (Cools-Lartigue et al., 2013).”
- Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment (2016, background): “The recent identification of TAN specific signatures such as CD62LloCD54hi phenotype with a distinct repertoire of chemokine receptors including CCR5, CCR7, CXCR3, and CXCR4 in human lung cancer indicates that further study to validate TAN specific NETosis may be possible in animal studies [79].”
- Origins, structures, and functions of circulating DNA in oncology (2016, background): “DNase or neuro-elastase inhibitor treatment should also be effective in the destruction of NETs implicated in metastatic spreading by sequestration of CTCs [101].”
- Surgery for Cancer: A Trigger for Metastases. (2017, background): “Another promising approach derives from experimental studies that show that blocking the innate immune response, notably neutrophils, from forming NETs by administering DNAse can decrease metastases formation, presumably by decreasing entrapment of circulating cancer cells atmetastatic sites (7, 25)”